| Project/Area Number |
25670360
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Fujita Health University |
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Principal Investigator |
ATSUZAWA Kimie 藤田保健衛生大学, 医学部, 助教 (60387727)
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| Co-Investigator(Kenkyū-buntansha) |
USUDA Nobuteru 藤田保健衛生大学, 医学部, 教授 (30135123)
FUKASAWA Motoaki 藤田保健衛生大学, 医学部, 助教 (70387728)
MORIYAMA Yohsuke 藤田保健衛生大学, 医学部, 助教 (00452532)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 東洋医学 / 施灸 / ドパミン分泌 / パーキンソン病 |
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| Research Abstract |
The effect of moxibustion on normal and Parkinson's disease model animals were attempted to show its effects on dopamine secretion, motor and other symptoms. The moxibustion on normal rats resulted in the secretion of dopamine and c-fos expression in the striatum, also made the locomotor activity higher. The synthetic activity of dopamine shown by the presence of tyrosine hydroxylase was made decreased, and c-fos expression in the striatum in the animals administered with 6OHDA to the striatum. This may indicate the dopamine secretion induced by moxibustion regulates the function of the striatum. The body temperature of the animals administered with reserpine was made elevated by moxibustion. These reactions of animals to moxibustion, dopamine secretion in the striatum; its activation by dopamine; increased locomotor activity; and the elevation of the body temperature, were suggested to be effective for the treatment of the symptoms of Parkinson's disease.
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