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The role and molecular mechanisms of free-cholesterol toxicity in steatohepatitis

Research Project

Project/Area Number 25670365
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

OKAZAKI Sachiko  東京大学, 医学部附属病院, 病院診療医 (30648720)

Co-Investigator(Renkei-kenkyūsha) OKAZAKI Hiroaki  東京大学, 医学部附属病院, 助教 (80610211)
TAKANASHI Mikio  東京大学, 医学部附属病院, 特任助教 (70610799)
TAKASE Satoru  東京大学, 医学部附属病院, 助教 (80508094)
KUBOTA Midori  東京大学, 保健・健康推進本部, 助教 (20383804)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsコレステロール / リパーゼ / 非アルコール性脂肪性肝炎 / 脂肪肝 / 脂肪毒性 / 炎症 / 分子標的
Outline of Final Research Achievements

Fatty liver has been recognized not only as a complication of metabolic syndrome but also as a causative factor of steatohepatitis, liver cirrhosis and hepatocellular carcinoma. However, the mechanism how fatty liver progresses to steatohepatitis is not fully understood. Our study was aimed at elucidating the role of lipases in fatty liver and suggested that increased hydrolysis of cholesterol ester and production of free cholesterol in liver may promote inflammation in fatty liver. The exact molecular mechanism is under further investigation.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013

All Presentation (5 results)

  • [Presentation] 肝臓ホルモン感受性リパーゼ過剰発現による遊離コレステロール蓄積性肝炎の発症機序2014

    • Author(s)
      岡崎佐智子
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] コレステロールエステル蓄積型脂肪肝におけるリパーゼ過剰発現による致死的肝炎の発症機序2014

    • Author(s)
      岡崎佐智子
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Presentation] コレステロールエステル蓄積型脂肪肝におけるホルモン感受性リパーゼ過剰発現は肝炎を来す2013

    • Author(s)
      岡崎佐智子
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪肝におけるリパーゼ過剰発現による致死的肝炎2013

    • Author(s)
      岡崎佐智子
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪肝モデルマウスへのホルモン感受性リパーゼ過剰発現による致死的肝炎2013

    • Author(s)
      岡崎佐智子
    • Organizer
      日本肥満学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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