| Project/Area Number |
25670378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
TSUTSUI Hiroyuki 北海道大学, 医学(系)研究科(研究院), 教授 (70264017)
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| Co-Investigator(Kenkyū-buntansha) |
KINUGAWA Shintaro 北海道大学, 大学院医学研究科, 講師 (60399871)
ISHIMORI Naoki 北海道大学, 大学院医学研究科, 助教 (70399848)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 急性心筋梗塞 / 心破裂 / 炎症性サイトカイン / ナチュラルキラーT細胞 / α-ガラクトシルセラミド / αーガラクトシルセラミド |
|---|
| Research Abstract |
Myocardial infarction (MI) leads to the development of cardiac rupture as well as heart failure, both of which are the major causes of death in post-MI patients. Chronic tissue inflammation plays an important role in the pathological process of post-MI left ventricular remodeling as well as cardiac rupture. Invariant natural killer T (iNKT) cells orchestrate tissue inflammation via regulating the production of various cytokines. The activation of iNKT cells by alpha-galactosylceramide (alpha-GC), which specifically activates iNKT cells, could be beneficial to protect the heart from acute ischemic injury.
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