The possibility of pleiotropic effects of Novel Oral Anticoagulants (NOAC) on Rho-kinase-cyclophilin A System
Project/Area Number |
25670379
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Tohoku University |
Principal Investigator |
SHIMOKAWA Hiroaki 東北大学, 医学(系)研究科(研究院), 教授 (00235681)
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Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | シグナル伝達 / スタチン / 低分子量G蛋白 / サイクロフィリンA / 心血管疾患 / 平滑筋増殖 / バイオマーカー / Rhoキナーゼ / 新規抗凝固薬 / Xa阻害薬 |
Outline of Final Research Achievements |
We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation.2014
Author(s)
Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
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Journal Title
Circ Res.
Volume: 115
Issue: 8
Pages: 738-750
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice.2014
Author(s)
Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y., and Shimokawa, H.
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Journal Title
Arterioscler. Thromb. Vasc Biol.
Volume: 34
Issue: 6
Pages: 1260-1271
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH).2014
Author(s)
Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 34
Issue: 11
Pages: 2486-2494
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study.2014
Author(s)
Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
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Journal Title
Eur Heart J Cardiovasc Imaging.
Volume: 15
Issue: 6
Pages: 666-672
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] OCT imaging for the management of pulmonary hypertension.2014
Author(s)
Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
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Journal Title
JACC-Cardiovasc Imaging.
Volume: 7
Issue: 8
Pages: 843-845
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension.2014
Author(s)
Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H.
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Journal Title
Circ J.
Volume: 78
Pages: 2771-2773
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Extracorporeal low-energy shock wave therapy exerts anti-inflammatory effects in acute myocardial infarction in rats in vivo.2014
Author(s)
Abe Y, Ito K, Hao K, Shindo T, Ogata T, Kagaya Y, Kurosawa R, Nishimiya K, Satoh K, Miyata S, Kawakami K, Shimokawa H.
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Journal Title
Circ J.
Volume: 78
Pages: 2915-2925
Related Report
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[Journal Article] Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registrystudy of the Japanese Coronary Spasm Association-2013
Author(s)
Takagi Y, Yasuda S, Takahashi J, TsunodaR, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H
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Journal Title
Eur Heart J
Volume: 34
Issue: 4
Pages: 258-267
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease2013
Author(s)
Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
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Journal Title
Circulation Journal
Volume: 77
Issue: 2
Pages: 447-455
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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