Identification of effective agent against abdominal aortic aneurysm formation

• Project/Area Number: 25670380
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: MORITA Hiroyuki 東京大学, 医学部附属病院, 准教授 (60323573)
• Co-Investigator(Kenkyū-buntansha): 中山 敦子 東京大学, 医学部附属病院, 助教 (60529147)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 大動脈瘤 / ルテオリン / フラボノイド

Research Abstract

The purpose of this study is to identify plant-derived agent having a protective effect on the abdominal aortic aneurysm formation, which can be orally administered for a long period. As a result, oral administration of luteolin, which is a widely distributed flavonoid found in many herbal extracts, was demonstrated to inhibit significantly the abdominal aortic aneurysm formation in the experimental model. Also, these effects were observed in a dose-dependent manner. Further studies are warranted to draw the clear conclusions on the more appropriate quantity and method for intake of this powerful flavonoid.

Research Products

• [Journal Article] Predictors of mortality after emergency or elective repair of abdominal aortic aneurysm in a Japanese population (2014)
  • Author(s): Nakayama A, Morita H, Miyata T, Hoshina K, Nagayama M, Takanashi S, Sumiyoshi T, Komuro I, Nagai R.
  • Journal Title: Heart and Vessels Volume: 29 Pages: 65-70
• [Journal Article] 遺伝子から心筋症をみる (2014)
  • Author(s): 森田啓行
  • Journal Title: 日本内科学会雑誌 Volume: 103(2) Pages: 285-292
• [Journal Article] M. Human genomics in cardiovascular medicine; implications and perspectives (2013)
  • Author(s): Morita H
  • Journal Title: Circulation Journal Volume: 77 Pages: 876-885
• [Journal Article] Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous coronary intervention (2013)
  • Author(s): Nakayama A, Morita H, Ando J, Fujita H, Ohtsu H, Nagai R
  • Journal Title: Heart and Vessels Volume: 28 Pages: 292-300
• [Journal Article] Melatonin ameliorates Angiotensin II-induced vascular endothelial damage via its antioxidative properties (2013)
  • Author(s): Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I
  • Journal Title: Journal of Pineal Research Volume: 55 Pages: 287-293
• [Journal Article] Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy-prospective multicenter cohort study- (2013)
  • Author(s): Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I
  • Journal Title: International Journal of Cardiology Volume: 168 Pages: 1900-1904
• [Journal Article] A novel channelopathy in pulmonary arterial hypertension (2013)
  • Author(s): Morita H, Komuro I
  • Journal Title: New England Journal of Medicine Volume: 369 Pages: 2161-2162
• [Journal Article] Genetic variants and dilated cardiomyopathy - To be or not to be causative : Is that the question? (2013)
  • Author(s): Morita H
  • Journal Title: Circulation Journal Volume: 77 Pages: 2879-2880
  • NAID: 10031203568
• [Journal Article] 肥大型心筋症の遺伝子診断 : 推進に向けての方策 (2013)
  • Author(s): 森田啓行 ,山田奈美恵 ,小室一成
  • Journal Title: 日本内科学会雑誌 Volume: 102(5) Pages: 1233-1242
  • NAID: 10031185304
• [Journal Article] Human Genomics in Cardiovascular Medicine (2013)
  • Author(s): Morita H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 4 Pages: 876-885
  • DOI: 10.1253/circj.CJ-13-0126
  • NAID: 10031138983
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Melatonin ameliorates angiotensin ii-induced vascular endothelial damage via its antioxidative properties. (2013)
  • Author(s): Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I.
  • Journal Title: J Pineal Res Volume: 55 Issue: 3 Pages: 287-293
  • DOI: 10.1111/jpi.12071
  • Peer Reviewed
• [Journal Article] Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy-prospective multicenter cohort study-. (2013)
  • Author(s): Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I.
  • Journal Title: Int J Cardiol. Volume: 168 Pages: 1900-1904
  • Peer Reviewed
• [Journal Article] Predictors of mortality after emergency or elective repair of abdominal aortic aneurysm in a Japanese population (2012)
  • Author(s): Nakayama A, Miyata T
  • Journal Title: Heart and Vessels Volume: - Issue: 1 Pages: 292-300
  • DOI: 10.1007/s00380-012-0319-5
  • Peer Reviewed
• [Presentation] Identification of novel susceptibility loci for myocardial infarction using large-scale genomic analysis (2014)
  • Author(s): 森田啓行
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Book] 内科学第 10版 5-4循環器疾患と遺伝子異常2)心筋症 (2013)
  • Author(s): 森田啓行
  • Publisher: 朝倉書店
• [Book] 内科学書改訂第 8版 循環器疾患と遺伝子異常 (2013)
  • Author(s): 森田啓行,永井良三
  • Publisher: 中山書店