Identification of effective agent against abdominal aortic aneurysm formation
| Project/Area Number |
25670380
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中山 敦子 東京大学, 医学部附属病院, 助教 (60529147)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 大動脈瘤 / ルテオリン / フラボノイド |
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| Research Abstract |
The purpose of this study is to identify plant-derived agent having a protective effect on the abdominal aortic aneurysm formation, which can be orally administered for a long period. As a result, oral administration of luteolin, which is a widely distributed flavonoid found in many herbal extracts, was demonstrated to inhibit significantly the abdominal aortic aneurysm formation in the experimental model. Also, these effects were observed in a dose-dependent manner. Further studies are warranted to draw the clear conclusions on the more appropriate quantity and method for intake of this powerful flavonoid.
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Report
(2 results)
Research Products
(16 results)
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[Journal Article] Melatonin ameliorates Angiotensin II-induced vascular endothelial damage via its antioxidative properties2013
Author(s)
Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I
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Journal Title
Journal of Pineal Research
Volume: 55
Pages: 287-293
Related Report
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[Journal Article] Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy-prospective multicenter cohort study-2013
Author(s)
Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I
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Journal Title
International Journal of Cardiology
Volume: 168
Pages: 1900-1904
Related Report
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[Journal Article] Melatonin ameliorates angiotensin ii-induced vascular endothelial damage via its antioxidative properties.2013
Author(s)
Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I.
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Journal Title
J Pineal Res
Volume: 55
Issue: 3
Pages: 287-293
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy-prospective multicenter cohort study-.2013
Author(s)
Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I.
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Journal Title
Int J Cardiol.
Volume: 168
Pages: 1900-1904
Related Report
Peer Reviewed
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