The functional role of mitochondria innermembrane fusion inhibitor in heart
Project/Area Number |
25670387
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SHINTANI Norihito 大阪大学, 薬学研究科, 准教授 (10335367)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 心肥大 / ミトコンドリア / 心不全 |
Outline of Final Research Achievements |
In cardiomyocytes, mitochondria play central roles in metabolism, energy production and cell death. Mitochondria maintain its homeostasis through continuous fusion and fission process. Mitochondrial inner-membrane fusion inhibitor (MIFI) regulates mitochondrial morphology via inhibiting inner-membrane fusion. Since the expression of MIFI is predominant in heart and decreased after myocardial infarction or pressure overload, we generated transgenic mice with cardiac specific overexpression of MIFI (MIFI-TG) to assess functional roles in cardiac pathophysiology. Overexpression of MIFI were confirmed by enhanced protein expression in heart and transgenic mice were obtained according to Mendelian’s law. While no overt cardiac phenotype was observed under physiological condition, MIFI-TG displayed accelerated cardiac hypertrophy and dysfunction, suggesting mitochondrial morphological changes caused by MIFI are detrimental after stress stimulation in heart.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.2014
Author(s)
Shintani Y, Drexler HC, Kioka H, Terracciano CM, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K, Suzuki K.
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Journal Title
EMBO Reports
Volume: 15
Issue: 4
Pages: 438-445
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum.2014
Author(s)
Morimoto S, Hongo K, Kusakari Y, Komukai K, Kawai M, O-Uchi J, Nakayama H, Asahi M, Otsu K, Yoshimura M, Kurihara S.
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Journal Title
Cell Calcium.
Volume: 55
Issue: 1
Pages: 17-23
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] ミトコンドリア融合阻害因子MIFIによる心病態の増悪機序に関する解析 - 遺伝子発現プロフィール解析 -2014
Author(s)
田中 翔大, 新谷 紀人, 中山 博之, 東 信太朗, 開 菜摘, 舎川 洸太, 藤尾 慈, 井上 直紀, 笠井 淳司, 早田 敦子, 橋本 均, 馬場 明道
Organizer
第125回 日本薬理学会近畿部会
Place of Presentation
岡山コンベンションセンター(岡山県岡山市)
Year and Date
2014-06-20
Related Report
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[Presentation] 新規ミトコンドリア融合阻害因子MIFIの心筋特異的過剰発現マウスを用いた生理・病態機能解析2013
Author(s)
開 菜摘, 新谷 紀人 , 東 信太朗, 舎川 洸太, 中山 博之, 藤尾 慈, 井上 直紀, 田中 翔太, 笠井 淳司, 早田 敦子, 馬場 明道, 橋本 均
Organizer
第124回日本薬理学会近畿部会
Place of Presentation
京都ガーデンパレス(京都)
Related Report