Research Project
Grant-in-Aid for Challenging Exploratory Research
The only effective therapy for ischemic cardiomyopathy is heart transplantation. However, only limited numbers of donors are available in Japan. Therefore, we tried to establish a new strategy to substitute heart transplantation. Histological analysis of human endarterectomy samples and epicardial fat obtained during cardiac bypass surgery revealed enhanced infiltration of inflammatory cells such as macrophages and T cells not only in vessel wall but also in perivascular adipose tissues. We also found that interaction between cell-free DNA released from adipocytes and TLR9 on macrophages plays a crucial role in chronic inflammation in adipose tissues. Based on these observations, we started to develop a new surgical strategy to treat patients with ischemic cardiomyopathy by reconstructing coronary artery with exogenous artery and subcutaneous adipose tissues.
All 2014 2013 Other
All Journal Article (57 results) (of which Peer Reviewed: 41 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (145 results) (of which Invited: 3 results) Book (5 results) Remarks (1 results)
Circulation Journal
Volume: 78 Issue: 1 Pages: 240-247
10.1253/circj.CJ-13-0741
130003382181
Eur. J. Pharmacol.
Volume: 699 Issue: 1-3 Pages: 81-87
10.1016/j.ejphar.2012.11.045
Volume: 699 Issue: 1-3 Pages: 106-111
10.1016/j.ejphar.2012.11.057
The Journal of Thoracic and Cardiovascular Surgery
Volume: 145 Issue: 2 Pages: 522-530
10.1016/j.jtcvs.2012.03.010
International Heart Journal
Volume: 54 Issue: 1 Pages: 51-53
10.1536/ihj.54.51
130003364440
J Am Coll Cardiol.
Volume: 61 Issue: 8 Pages: e147-e147
10.1016/j.jacc.2012.10.047
Volume: 77 Issue: 3 Pages: 786-788
10.1253/circj.CJ-12-1098
10031138972
J Mol Cell Cardiol
Volume: 57 Pages: 1-12
10.1016/j.yjmcc.2013.01.004
Heart Asia
Volume: 5 Issue: 1 Pages: 42-43
10.1136/heartasia-2013-010287
The Journal of Medical Investigation
Volume: 60 Issue: 1.2 Pages: 97-105
10.2152/jmi.60.97
130004465299
Volume: 60 Issue: 1.2 Pages: 1-14
10.2152/jmi.60.1
130004465276
JACC Cardiovasc Imaging.
Volume: 6 Issue: 4 Pages: 528-530
10.1016/j.jcmg.2012.10.025
Arterioscler. Thromb. Vasc. Biol.
Volume: 33 Issue: 5 Pages: 1077-1084
10.1161/atvbaha.112.300829
Journal of Cardiology Cases
Volume: 7 Issue: 4 Pages: e91-e92
10.1016/j.jccase.2012.10.011
Volume: in press Issue: 6 Pages: e176-e180
10.1016/j.jccase.2013.02.009
International Journal of Cardiology
Volume: in press Issue: 1 Pages: 298-300
10.1016/j.ijcard.2012.09.194
Acta Cardiol Sin
Volume: 29巻 Pages: 201-207
Hypertension Research
Volume: in press Issue: 7 Pages: 586-587
10.1038/hr.2013.27
Circulation
Volume: 128巻 Pages: 60-71
Cardiovascular Intervention and Therapeutics
Volume: in press Issue: 3 Pages: 287-90
10.1007/s12928-013-0158-z
Cardiovasc Res
Volume: 99 Issue: 4 Pages: 705-715
10.1093/cvr/cvt146
J Cereb Blood Flow Metab
Volume: 33 Issue: 8 Pages: 1153-1159
10.1038/jcbfm.2013.62
Int J Cardiol
Volume: 167 Issue: 5 Pages: 2108-2113
10.1016/j.ijcard.2012.05.109
Arterioscler Thromb Vasc Biol
Volume: 33巻 Issue: 10 Pages: 2286-2287
10.1161/atvbaha.113.302315
Atherosclerosis
Volume: 231 Issue: 2 Pages: 227-233
10.1016/j.atherosclerosis.2013.09.010
J Surg Res
Volume: 185 Issue: 1 Pages: 455-462
10.1016/j.jss.2013.05.002
Life Sciences.
Volume: 93 Issue: 22 Pages: 814-819
10.1016/j.lfs.2013.09.005
Hypertension research : official journal of the Japanese Society of Hypertension
Volume: 36 Issue: 9 Pages: 753-758
10.1038/hr.2013.51
Volume: in press Issue: 6 Pages: 271-277
10.1016/j.jtcvs.2013.02.073
J Am Heart Assoc
Volume: 2 Issue: 6
10.1161/jaha.113.000267
Heart Vessels
Volume: 28 Issue: 6 Pages: 795-801
10.1007/s00380-013-0333-2
J Med Invest.
Volume: 60 Pages: 97-105
Volume: 60 Pages: 1-14
Acta Cardiol Sin.
Volume: 29 Pages: 201-207
Circulation.
Volume: 128 Pages: 60-71
Angiotension Research
Volume: 10 Pages: 59-63
循環plus
Volume: 13 Pages: 2-6
心臓リハビリテーション
Volume: 18 Pages: 130-133
日本冠疾患学会雑誌
Volume: 19 Pages: 36-36
130003379655
循環器専門医
Volume: 21 Pages: 132-134
Volume: 21 Pages: 16-16
Volume: 21 Pages: 97-97
腎・高血圧の最新治療
Volume: 2 Pages: 92-97
月刊 循環器 CIRCULATION
Volume: 3 Pages: 25-31
J-ISCP会誌 心血管薬物療法
Volume: 1 Pages: 3-9
四国医学雑誌
Volume: 1 Pages: 21-28
Vascular Medicine
Volume: 9 Pages: 12-12
Volume: 9 Pages: 29-34
医学のあゆみ
Volume: 245 Pages: 615-617
循環器内科
Volume: 73 Pages: 667-671
Mebio
Volume: 30 Pages: 7-7
Volume: 30 Pages: 98-107
Cardio-Renal Diabetes
Volume: 2 Pages: 4-7
Fluid Management Renaissance
Volume: 3 Pages: 34-42
CardioVascular Contemporary
Volume: 2 Pages: 14-19
血圧
Volume: 20 Pages: 30-34
Volume: 14 Pages: 2-6
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