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Identifying a factor contributing to gender difference in familial dilated cardiomyopathy

Research Project

Project/Area Number 25670393
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cardiovascular medicine
Research InstitutionNara Medical University

Principal Investigator

SAITO Yoshihiko  奈良県立医科大学, 医学部, 教授 (30250260)

Co-Investigator(Kenkyū-buntansha) 尾上 健児  奈良県立医科大学, 医学部, 助教 (90510173)
Research Collaborator 木村 彰方   (60161551)
瀬藤 光利   (20302664)
重信 秀治   (30399555)
Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords循環器・高血圧 / 性差 / 心筋症
Research Abstract

Gender difference is well known in cardiovascular disorder. Prevalence of ischemic heart disease is lower in female, or the age at risk of heart failure is higher in female. In this study, we tried to unveil the mechanism of gender difference in cardiovascular disease.
At first, we analyzed gene mutation in patients with familial dilated cardiomyopathy, and found a mutation in a gene which codes inner nucleus membrane protein, lamin. Next, we focused on sex hormone, and found that androgen receptor accumulated in nucleus of cardiomyocyte only in those who had the mutation. Currently we're still continuing to seek the mechanism of gender difference by utilizing lamin knock out mice. We would like to contribute to the progression of cardiovascular field by studying this gender difference issue more in detail.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (14 results)

All 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations2013

    • Author(s)
      Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne G, Kimura A.
    • Journal Title

      Cardiovasc Res

      Pages: 382-394

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance : a feasibility study2013

    • Author(s)
      Okayama S, Nakano T, Uemura S, Fujimoto S, omekawa S, Watanabe M, Nakajima T, Saito Y.
    • Journal Title

      J Cardiovasc Magn Reson

      Pages: 87-92

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy2013

    • Author(s)
      Okayama S, Uemura S, Saito Y.
    • Journal Title

      Int J Cardiol

      Pages: 43-45

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations2013

    • Author(s)
      Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou M, Shigenbu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato M, Tanaka R, Somekawa T, Nakano T, Yamane Y, Kuba K, Imai Y, Saito N, Bonne G, Kimura A
    • Journal Title

      Cardiovasc Res

      Volume: (in press) Issue: 3 Pages: 382-394

    • DOI

      10.1093/cvr/cvt106

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.2013

    • Author(s)
      Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M, Nakajima T, Saito Y.
    • Journal Title

      J Cardiovasc Magn Reson.

      Volume: 15 Issue: 1 Pages: 87-87

    • DOI

      10.1186/1532-429x-15-87

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of epicardial and intra-myocardial fat in a patient with mitochondrial cardiomyopathy2013

    • Author(s)
      Okayama S, Uemura S, Saito Y
    • Journal Title

      Int J Cardiol

      Volume: Epub ahead of print Issue: 2 Pages: 0-1

    • DOI

      10.1016/j.ijcard.2013.03.054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Molecular Mechanism of Gender Difference in Heart Failure Caused by Lamin A/C Mutations2014

    • Author(s)
      Kimura A, Arimura T, Onoue K, Ishikawa T, Saito Y.
    • Organizer
      日本循環器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular Mechanism of Gender Difference in Heart Failure Caused by Lamin A/C Mutations2014

    • Author(s)
      Kimura A, Arimura T, Onoue K, et al.
    • Organizer
      日本循環器学会
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Worsening of Renal Function after One Year, Not During Hospitalization, is Stronger Predictor of Prognosis in Patients With ADHF2013

    • Author(s)
      Ueda T, Kawakami R, Sugawara Y, Matsumoto T, Okada S, Soeda T, Okayama S, Somekawa S, Takeda Y, Watanabe M, Kawata H, Uemura S, Saito Y.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Uremic Toxin Aggravates Atherosclerosis by Suppression of Endothelial Soluble Flt-1 Production in CKD2013

    • Author(s)
      Takeda Y, Uemura S, Matsui M, Matsumoto T, Seno A, Okada S, Nishida T, Soeda T, Okayama S, Somekawa S, Watanabe M, Kawata H, Kawakami R, Saito Y.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Uremic Toxin Aggravates Atherosclerosis by Suppression of Endothelial Soluble Flt-1 Production in CKD.2013

    • Author(s)
      Takeda Y, Uemura S, et al.
    • Organizer
      American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Worsening of Renal Function after One Year, Not During Hospitalization, is Stronger Predictor of Prognosis in Patients with ADHF.2013

    • Author(s)
      Ueda T, Kawakami R, et al.
    • Organizer
      American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.naramed-u.ac.jp/~1int/

    • Related Report
      2013 Final Research Report
  • [Remarks] 奈良県立医科大学第1内科

    • URL

      http://www.naramed-u.ac.jp/~1int/

    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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