Development of a novel renal functional evaluation strategy by positron emission tomography imaging in human.
Project/Area Number |
25670405
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Tohoku University |
Principal Investigator |
Ito Sadayoshi 東北大学, 医学(系)研究科(研究院), 教授 (40271613)
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Co-Investigator(Kenkyū-buntansha) |
IWATA REN 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
TASHIRO MANABU 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
MORI TAKEFUMI 東北大学, 大学院医学系研究科, 准教授 (40375001)
OHSAKI YUSUKE 東北大学, 大学院医学系研究科, 助教 (40509212)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 腎臓 / 画像評価法 / 腎機能 / ポジトロン断層法(PET) / 腎不全 / 局所血流評価 / イメージング / 画像解析 / 腎機能評価 / 局所腎血流量 / 腎臓髄質血流 / 腎臓病 / 画像評価 / 腎局所血流 / 腎障害 |
Outline of Final Research Achievements |
In this study, we tried to develop a novel renal functional evaluation strategy by positron emission tomography imaging in human. [15O]H2O-PET images of healthy volunteers and end stage renal disease (ESRD) patients were captured. Renal local blood flow did not changed in the dehydrated condition compared to the hydrated condition. However, the renal local blood flow was significantly decreased in ESRD patients compared to healthy volunteer. These findings indicate that [15O]H2O-PET imaging could be one of the tool of evaluation for the renal medulla functions.
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Report
(4 results)
Research Products
(93 results)
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[Journal Article] Urinary angiotensinogen excretion is associated with blood pressure in obese young adults.2016
Author(s)
Sato E, Mori T, Satoh M, Fujiwara M, Nakamichi Y, Oba I, Ogawa S, Kinouchi Y, Sato H, Ito S, Hida W.
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Journal Title
Clin Exp Hypertens.
Volume: 38
Issue: 2
Pages: 203-208
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats.2013
Author(s)
Chen x, Mori T, Guo Q, Hu C, Ohsaki Y, Yoneki Y, Zhu W, Jiang Y, Endo S, Nakayama K, Ogawa S, Nakayama M, Miyata T, Ito S
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Journal Title
Hypertens Res.
Volume: (印刷中)
Issue: 4
Pages: 361-367
DOI
Related Report
Peer Reviewed
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[Journal Article] Beneficial Role of Tolvaptan in the Control of Body Fluids Without Reductions in Residual Renal Function in Patients Undergoing Peritoneal Dialysis.2013
Author(s)
Takefumi Mori, Ikuko Oba, Kenji Koizumi, Mayumi Kodama, Miwako Shimanuki, Mizuho Tanno, Makiko Chida, Mai Saito, Hideyasu Kiyomoto, Mariko Miyazaki, Susumu Ogawa, Hiroshi Sato, Sadayoshi Ito
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Journal Title
Advances in Peritoneal Dialysis
Volume: 29
Pages: 33-37
Related Report
Peer Reviewed
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[Presentation] PLASMA FREE AMINO ACIDS IN PATIENTS UNDERGOING PERITONEAL DIALYSIS.2015
Author(s)
Naho Kurasawa, Takefumi Mori, Kenji Koizumi, Shinichi Sato, Ikuko Yabana, Satoshi Shimada, Yusuke Ohsaki, Emiko Sato, Eri Naganuma, Mihoko Tuchikawa, Sadayoshi Ito
Organizer
EURO PD 2015
Place of Presentation
Krakow, Poland
Year and Date
2015-10-02
Related Report
Int'l Joint Research
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[Presentation] ANGIOTENSIN INDEPENDENT ROLE OF (PRO)RENIN RECEPTOR IN HUMAN PERITONEAL MESOTHELIAL CELLS.2015
Author(s)
Ikuko Yabana, Takefumi Mori, Chika Takahashi, Yusuke Ohsaki, Emiko Sato, Takuo Hirose, Genevieve Nguyen, Remi Piedagnel, Pierre Ronco, Sadayoshi Ito
Organizer
EURO PD 2015
Place of Presentation
Krakow, Poland
Year and Date
2015-10-02
Related Report
Int'l Joint Research
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[Presentation] Role of long-term treatment of tolvaptan on left ventricular mass index in patients undergoing peritoneal dialysis.2015
Author(s)
Kenji Koizumi, Takefumi Mori, Yusuke Ohsaki, Ikuko Ohba, Shinichi Sato, Satoshi Shimada, Eri Naganuma, Naho Kurasawa, Mihoko Tsuchikawa, Sadayoshi Ito.
Organizer
APCM-ISPD 2015
Place of Presentation
Daegu, Korea
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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[Presentation] Association between clinical parameters and upper arm circumference of the patients undergoing peritoneal dialysis.2015
Author(s)
Mihoko Tuchikawa, Takefumi Mori, Makiko Chida, Naho Kurasawa, Ikuko Yabana, Kenji Koizumi, Shinichi Sato, Satoshi Shimada, Eri Naganuma, Sadayoshi Ito
Organizer
APCM-ISPD 2015
Place of Presentation
Daegu, Korea
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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[Presentation] 二次性高血圧の鑑別2014
Author(s)
森建文
Organizer
第58回日本腎臓学会学術総会
Place of Presentation
パシフィコ横浜(横浜)
Year and Date
2014-07-06
Related Report
Invited
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[Presentation] Functional (pro)renin receptor in human lymphocytes and monocytes.
Author(s)
Kaori Narumi, Takuo Hirose, Emiko Sato, Takefumi Mori, Yusuke Ohsaki, Kiyomi Kisu, Mayuko Ishikawa, Tomonori Ishii, Hiroshi Sato, Sadayoshi Ito
Organizer
World congress of Nephrology 2013
Place of Presentation
Hong Kong, China
Related Report
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