| Project/Area Number |
25670405
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Ito Sadayoshi 東北大学, 医学(系)研究科(研究院), 教授 (40271613)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA REN 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
TASHIRO MANABU 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
MORI TAKEFUMI 東北大学, 大学院医学系研究科, 准教授 (40375001)
OHSAKI YUSUKE 東北大学, 大学院医学系研究科, 助教 (40509212)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 腎臓 / 画像評価法 / 腎機能 / ポジトロン断層法(PET) / 腎不全 / 局所血流評価 / イメージング / 画像解析 / 腎機能評価 / 局所腎血流量 / 腎臓髄質血流 / 腎臓病 / 画像評価 / 腎局所血流 / 腎障害 |
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| Outline of Final Research Achievements |
In this study, we tried to develop a novel renal functional evaluation strategy by positron emission tomography imaging in human. [15O]H2O-PET images of healthy volunteers and end stage renal disease (ESRD) patients were captured. Renal local blood flow did not changed in the dehydrated condition compared to the hydrated condition. However, the renal local blood flow was significantly decreased in ESRD patients compared to healthy volunteer. These findings indicate that [15O]H2O-PET imaging could be one of the tool of evaluation for the renal medulla functions.
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