| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It has been well known that Aβ oligomers are synaptotoxic and molecular basis of memory loss, which is candidate molecules for drug development in Alzheimer’s disease. We aimed to develop a novel vaccine targeting Aβ oligomers alone to assess if the appearance of neutralizing antibody against parent one is really problematic or not from therapeutic point of view. It was easy to make neutralizaing antibodies. However, when anti-ideotype antibodies themselves were directly immunized to mouse pad, we can hardly detect anti-ideotypic antibodies in blood obtained from immunized mice, suggesting that we need to design something like anti-ideotype vaccine to retrieve of in vivo action.
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