Developing a cell transplantation therapy for chronic multiple sclerosis by using Schwann cells induced from mesenchymal stem cells
| Project/Area Number |
25670423
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
KIRA Jun-ichi 九州大学, 医学(系)研究科(研究院), 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takuya 九州大学, 大学院医学研究院, 准助教 (00533001)
MATSUSE Dai 九州大学, 大学院医学研究院, 助教 (70596395)
河野 祐治 九州大学, 医学(系)研究科(研究院), 研究員 (20333479)
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| Research Collaborator |
OGATA Hidenori 九州大学, 大学院医学研究院
FUJITA Atsushi 九州大学, 大学院医学研究院
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 間葉系幹細胞 / 細胞移植 / 多発性硬化症 / シュワン細胞 / 脱髄モデル / 自己免疫性脳脊髄炎 |
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| Outline of Final Research Achievements |
The aim of this project is to develop a novel cell transplantation therapy for chronic multiple sclerosis. Schwann cells were induced from rat bone marrow mesenchymal stem cells by adding several cytokines. Experimental autoimmune encephalomyelitis (EAE) and toxin(Cuprizone or Ethidium bromide)-induced focal demyelinating model rat were prepared as chronic demyelinating animal models. Induced Schwann cells were transplanted into these models, but no significant therapeutic effect could be observed. The instability of symptom of animal models might be one of the reason. But the low rate of transplanted cell engraftment was thought to be the primary cause of this result.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Anti-neurofascin antibody in patients with combined central and peripheral demyelination2013
Author(s)
Nobutoshi Kawamura, Ryo Yamasaki, Tomomi Yonekawa, Takuya Matsushita, Susumu Kusunoki, Shigemi Nagayama, Yasuo Fukuda, Hidenori Ogata, Dai Matsuse, Hiroyuki Murai, Jun-ichi Kira
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Journal Title
Neurology
Volume: 81
Issue: 8
Pages: 714-722
DOI
Related Report
Peer Reviewed
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[Presentation] Combined Central and Peripheral Demyelination: Diagnostic Value of Anti-Neurofascin Antibody and the First Nationwide Survey In Japan2013
Author(s)
Ogata H, Yamasaki R, Matsuse D, Kawamura N, Yonekawa T, Matsushita T, Imamura S, Kusunoki S, Nagayama S, Fukuda Y, Murai H, Kira JI
Organizer
the 6th Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
Place of Presentation
Kyoto
Related Report
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