Reclassification of multiple sclerosis with new modality visualizing myelin status
Project/Area Number |
25670424
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Keio University |
Principal Investigator |
Nakahara Jin 慶應義塾大学, 医学部, 助教 (60537950)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 多発性硬化症 / 髄鞘 / 可視化技術 / MRI / 病型分類 |
Outline of Final Research Achievements |
Previous pathological studies confirmed the presence of heterogeneity in remyelination capacity among multiple sclerosis patients and such capacity may influence the prognosis of the disease. Due to the lack of clinically feasible methods to visualize remyelination, the proof of such heterogeneity in real world clinical practice has been difficult. The researchers recently succeeded to develop a new MRI modality (Myelin Mapping) to visualize myelin for the purpose. In the current study, a clinical study was performed for multiple sclerosis patients to apply the modality, and results suggested that the heterogeneity of remyelination capacity does exist in multiple sclerosis and that such capacity may be influenced by administration of certain drugs.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter2016
Author(s)
Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
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Journal Title
Journal of Neuroscience
Volume: 36(9)
Issue: 9
Pages: 2796-2808
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Improvement of EDSS in a subset of Japanese MS patients treated with Fingolimod: A possible association with remyelination.2015
Author(s)
Nakahara J, Tanikawa M, Suzuki S, Takahashi S, Fujiyoshi K, Hikishima K, Fujiwara H, Momoshima S, Jinzaki M, Nakamura M, Okano H, Suzuki N.
Organizer
31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
Place of Presentation
バルセロナ(スペイン)
Year and Date
2015-10-07
Related Report
Int'l Joint Research
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