Analyses for extracellular matrix in neuronal stem cell niche of aged brain
Project/Area Number |
25670426
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 成体神経新生 / 細胞外マトリックス / ヘパラン硫酸鎖 / 老化 / 神経新生 / ニッチ / 糖鎖 |
Outline of Final Research Achievements |
The subventricular zone (SVZ) is one of the area for neurogenesis in adult brain. In the SVZ neurogenic niche, specialized extracellular matrix (ECM) structures, fractones contact neural stem cells. We previously showed that heparan sulfate proteoglycan in the fractones regulate the growth factor activity and promote neurogenesis. We analyze the effect of aging on structure of fractones and composition of ECM molecules. Here, we report that fractone size significantly increased but fractone number significantly decreased with aging. Furthermore, we observed that the heparan sulfate chains contained in fractones were changed with aging. These results suggest that the change of morphology and specific composition of sugar chain in fractones may be related to decrease in neurogenesis in the aged SVZ.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.2014
Author(s)
Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi H, Arikawa-Hirasawa E, Yamada Y, Akazawa C.
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Journal Title
FASEB J.
Volume: 28(3)
Issue: 3
Pages: 1386-97
DOI
Related Report
Peer Reviewed
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[Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.2014
Author(s)
Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Ueno T.
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Journal Title
Autophagy
Volume: 10
Issue: 4
Pages: 631-41
DOI
Related Report
Peer Reviewed
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[Journal Article] PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.2014
Author(s)
Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T.
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Journal Title
Related Report
Peer Reviewed
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