| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The subventricular zone (SVZ) is one of the area for neurogenesis in adult brain. In the SVZ neurogenic niche, specialized extracellular matrix (ECM) structures, fractones contact neural stem cells. We previously showed that heparan sulfate proteoglycan in the fractones regulate the growth factor activity and promote neurogenesis. We analyze the effect of aging on structure of fractones and composition of ECM molecules. Here, we report that fractone size significantly increased but fractone number significantly decreased with aging. Furthermore, we observed that the heparan sulfate chains contained in fractones were changed with aging. These results suggest that the change of morphology and specific composition of sugar chain in fractones may be related to decrease in neurogenesis in the aged SVZ.
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