Research Project
Grant-in-Aid for Challenging Exploratory Research
Recent epidemiologic evidence suggests that type 2 diabetes and obesity are at significantly higher risk for many types of cancer. In this context, p53 has been shown to control mitochondrial functions through regulation of ROS and cell metabolism, implicating its potential role in biologic links between diabetes and cancer. Here we have explored p53 targets to regulate cell metabolism using ChIP- and RNA-sequencing and identified GLS2, a key enzyme to convert glutamine to glutamate, thereby a regulator of glutathione synthesis and ATP production via TCA cycle. GLS2 overexpression inhibited cancer cell growth as well as invasion in both vitro and vivo, suggesting its potential role for tumor suppression. Thus, p53-GLS2 pathway may contribute to the common pathogenesis between life-style related diseases and cancer.
All 2015 2014 2013
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Open Access: 1 results) Presentation (8 results) (of which Invited: 1 results) Book (1 results)
J Biol Chem
Volume: in press Issue: 21 Pages: 13095-13103
10.1074/jbc.m114.621524
Proc Natl Acad Sci U S A.
Volume: 110(46) Issue: 46 Pages: 18626-18631
10.1073/pnas.1311100110
Proc Natl Acad Sci U SA
Volume: - Issue: 12 Pages: 4691-4696
10.1073/pnas.1220865110
