Role of tumor suppressor p53 for aiming obesity and NASH and search for therapeutic targets
Project/Area Number |
25670438
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Chiba University |
Principal Investigator |
TANAKA Tomoaki 千葉大学, 医学(系)研究科(研究院), 准教授 (50447299)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | がん抑制遺伝子 / NASH / 生活習慣 / ROS / エネルギー代謝 / メタボローム / 生活習慣病 |
Outline of Final Research Achievements |
Recent epidemiologic evidence suggests that type 2 diabetes and obesity are at significantly higher risk for many types of cancer. In this context, p53 has been shown to control mitochondrial functions through regulation of ROS and cell metabolism, implicating its potential role in biologic links between diabetes and cancer. Here we have explored p53 targets to regulate cell metabolism using ChIP- and RNA-sequencing and identified GLS2, a key enzyme to convert glutamine to glutamate, thereby a regulator of glutathione synthesis and ATP production via TCA cycle. GLS2 overexpression inhibited cancer cell growth as well as invasion in both vitro and vivo, suggesting its potential role for tumor suppression. Thus, p53-GLS2 pathway may contribute to the common pathogenesis between life-style related diseases and cancer.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Methylation of Gata3 at Arg261 regulates transactivation of the Il5 gene in T helper 2 cells2015
Author(s)
Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T., and Nakayama, T.
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Journal Title
J Biol Chem
Volume: in press
Issue: 21
Pages: 13095-13103
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013
Author(s)
Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 110(46)
Issue: 46
Pages: 18626-18631
DOI
Related Report
Peer Reviewed
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[Presentation] p53 inducible Fdxr regulates iron metabolism and links to hepatic gluconeogenesis regulation through PGC1a activation.2015
Author(s)
13.Sakuma, I., Nakayama, A., Nagano, H., Hashimoto, N., Suzuki, S., Mayama, T., Koide, H., Yokote, K., Tanaka, T
Organizer
The Endocrine society’s 97th annual meeting & expo
Place of Presentation
San Diego, USA
Year and Date
2015-03-06 – 2015-03-07
Related Report
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