Suppression of breast cancer metastasis using the next generation nasal spray vaccine
Project/Area Number |
25670441
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | Mie University |
Principal Investigator |
KAWANO Mitsuo 三重大学, 医学(系)研究科(研究院), 講師 (00234097)
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Co-Investigator(Kenkyū-buntansha) |
KATO Takuma 三重大学, 大学院医学系研究科, 准教授 (60224515)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | hPIV2 / 乳癌 / 遺伝子免疫療法 / 腫瘍免疫 / 免疫活性化 / 細胞性免疫 / 液性免疫 / 転移 / PIV2 / 生体制御 |
Outline of Final Research Achievements |
Recently, we have established a novel functional replication-deficient virus vector; a recombinant human parainfluenza type 2 virus vector (hPIV2): highly safe, expressive and immunogenic vector. In this study, we have developed hPIV2 engineered to express Ag85B (hPIV2/Ag85B) and investigated antitumor effects against breast cancer metastasis by intranasal administration to a breast cancer like model mice generated by transplanting 4T1-Luc cells using the hPIV2/Ag85B. Especially, suppression effects of breast cancer metastasis were recognized in mouse lungs vaccinated high dose hPIV2/Ag85B.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Ribavirin inhibits human parainfluenza virus type 2 replication in vitro.2014
Author(s)
Kihira S, Uematsu J, Kawano M, Itoh A, Ookohchi A, Satoh S, Maeda Y, Sakai K, Yamamoto H, Tsurudome M, O'Brien M, Komada H.
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Journal Title
Microbiol Immunol.
Volume: 58
Issue: 11
Pages: 628-635
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.2014
Author(s)
Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
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Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis.2013
Author(s)
Kitagawa H, Kawano M, Yamanaka K, Kakeda M, Tsuda K, Inada H, Yoneda M, Sakaguchi T, Nigi A, Nishimura K, Komada H, Tsurudome M, Yasutomi Y, Nosaka T, Mizutani H.
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Journal Title
PLoS One.
Volume: 8
Issue: 7
Pages: 66614-66614
DOI
Related Report
Peer Reviewed
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