Origin of inflammatory cells constituting malignant lymphoma tissue
| Project/Area Number |
25670444
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性リンパ腫 / 炎症細胞 / 遺伝子変異 / がん / RHOA遺伝子 / TET2遺伝子 / DNMT3A遺伝子 |
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| Outline of Final Research Achievements |
Inflammatory cells participate in the malignant lymphoma tissues together with tumor cells. In this research, we demonstrated that tumor cells and inflammatory cells in the malignant lymphoma tissues have a common ancestor cell. In detail, a single hematopoietic progenitor cell becomes a “cancer-preparing cell” by sequentially acquiring gene mutations, which eventually produces tumor cells and inflammatory cells. This is the first to prove such a concept.
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Report
(3 results)
Research Products
(6 results)
