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Origin of inflammatory cells constituting malignant lymphoma tissue

Research Project

Project/Area Number 25670444
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

CHIBA Shigeru  筑波大学, 医学医療系, 教授 (60212049)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords悪性リンパ腫 / 炎症細胞 / 遺伝子変異 / がん / RHOA遺伝子 / TET2遺伝子 / DNMT3A遺伝子
Outline of Final Research Achievements

Inflammatory cells participate in the malignant lymphoma tissues together with tumor cells. In this research, we demonstrated that tumor cells and inflammatory cells in the malignant lymphoma tissues have a common ancestor cell. In detail, a single hematopoietic progenitor cell becomes a “cancer-preparing cell” by sequentially acquiring gene mutations, which eventually produces tumor cells and inflammatory cells. This is the first to prove such a concept.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Double somatic mosaic mutations in TET2 and DNMT3A-origin of peripheral T cell lymphoma in a case2015

    • Author(s)
      Nguyen TB, Sakata-Yanagimoto M, Nakamoto-Matsubara R, Enami T, Ito Y, Kobayashi T, Obara N, Hasegawa Y, Chiba S
    • Journal Title

      Annals of Hematology

      Volume: EPUB ahead of print Issue: 7 Pages: 1221-1223

    • DOI

      10.1007/s00277-015-2332-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.2014

    • Author(s)
      Sakata-Yanagimoto M, Yoshida K
    • Journal Title

      Nature Genet.

      Volume: 46 Issue: 2 Pages: 171-175

    • DOI

      10.1038/ng.2872

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Somatic mosaic mutations in TET2 and DNMT3A in a case of peripheral T-cell lymphoma2014

    • Author(s)
      Nguyen Bich Tran、千葉滋、他
    • Organizer
      第76回 日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Multi-step tumorigenesis in peripheral T-cell lymphoma2014

    • Author(s)
      Shigeru Chiba, Mamiko Sakata-Yanagimoto
    • Organizer
      6th T-cell Lymphoma Forum
    • Place of Presentation
      Parc 55 Wyndham(San Francisco, CA, U.S.A.)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 筑波大学血液内科

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] T細胞リンパ腫の検出方法2013

    • Inventor(s)
      千葉滋、坂田(柳元)麻実子、小川誠司
    • Industrial Property Rights Holder
      筑波大学、東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-096582
    • Filing Date
      2013-05-01
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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