| Project/Area Number |
25670450
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
YOKOYAMA Akihiko 京都大学, 医学(系)研究科(研究院), 准教授 (10506710)
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| Research Collaborator |
OKUDA Hiroshi 京都大学, 医学研究科, 特定助教 (10629215)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 自己複製 / 白血病 / ニッチ / 転写 / MLL / クロマチン / 癌 / 発現制御 / 生体分子 / 内科 / 蛋白質 |
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| Outline of Final Research Achievements |
Leukemia is often caused by a mutation which hyper-activates self-renewal. Normally self-renewal is controlled by the niche so that the stem cells are not overly produced. Some mutations such as MLL fusion are thought provoke niche-independent self-renewal to cause leukemia. In this research project, we investigated the mechanism by which MLL fusion stimulates self-renewal in the absence of the niche and proposed a novel mechanism of cell-autonomous self-renewal.
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