An exploratory study on the key molecules in Japanese autoimmune rheumatic diseases using genome and transcriptome analyses.
Project/Area Number |
25670458
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Hiroshi 国立病院機構相模原病院, 臨床研究センター, 室長 (00372293)
OHASHI Jun 東京大学, 理学系研究科, 准教授 (80301141)
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Research Collaborator |
KAWASAKI Aya 筑波大学, 医学医療系, 助教 (30532816)
HACHIYA Yuki 筑波大学, 大学院人間総合科学研究科
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 全身性エリテマトーデス / ANCA関連血管炎 / トランスクリプトーム / 遺伝子発現 / インターフェロン / 遺伝子発現プロファイル / ゲノム多型 |
Outline of Final Research Achievements |
Transcriptome analyses reveal not only the key molecules in the pathogenesis, but also novel susceptibility genes which influence expression levels. Here we compared transcriptomes of Japanese patients with active systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV) and healthy controls (HC). These groups were found to form distinct clusters. Significant enrichment of type I interferon related genes was detected not only in the differentially expressed genes in SLE, but also in AAV. Some of these genes exhibited opposite directions of expression change in SLE and AAV, suggesting that they might be related to the difference in the pathogenesis of these diseases. Furthermore, significant down-regulation of HLA class II genes was detected in AAV, suggesting that the molecular mechanism of association between HLA class II and AAV might involve reduced expression level. Thus, this exploratory study generated many testable hypotheses which should be validated in the future.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene2014
Author(s)
Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, NIicaise P, Amos C, Rodriguez-Rodriguez L, Chioccia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez-Gay MA, Furukawa H, Cantagrel A, Le Loet X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoriaty L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieude P
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Journal Title
Ann Rheum Dis
Volume: (Published Online First)
Issue: 3
Pages: e19-e19
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of IRF5 polymorphism with MPO-ANCA positive vasculitis in a Japanese population2013
Author(s)
Kawasaki A, Inoue N, Ajimi C, Sada K, Kobayashi S, Yamada H, Furukawa H, Sumida T, Tohma S, Miyasaka N, Matsuo S, Ozaki S, Hashimoto H, Makino H, Harigai M, Tsuchiya N
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Journal Title
Genes Immun
Volume: 14
Issue: 8
Pages: 527-529
DOI
Related Report
Peer Reviewed
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[Presentation] Association of functional polymorphisms in IRF2 with systemic lupus erythematosus (SLE) In a Japanese Population.2013
Author(s)
Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N.
Organizer
2013 American College of Rheumatology Annual Scientific Meeting
Place of Presentation
San Diego Convention Center(アメリカ合衆国)
Related Report
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