Clinical significance of anti-disulfide isomerase based on the AIRE research
Project/Area Number |
25670461
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Kyushu University |
Principal Investigator |
NAGAFUCHI Seiho 九州大学, 医学(系)研究科(研究院), 教授 (00150441)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 自己免疫調節遺伝子 / 自己抗体 / 自己免疫疾患 / Disulfide Isomerase / 自己免疫性膵炎 / Protein Isomerase |
Outline of Final Research Achievements |
Since we found auto antigen in Aire knockout mice associated with autoimmune pancreatitis was disulfide isomerase (DI), we conducted human anti-DI antibody detection study in various autoimmune diseases, including autoimmune pancreatitis, gastritis, primary biliary cirrhosis, sjogren syndrome and autoimmune retinitis. We developed western blot system as well as enzyme linked immunosorbent assay. we screened 200 cases, however, we could not detect any autoantibody. It was suggested improvement of assay system to detect anti-DI is essentially important and the study should be continued to solve the problems.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.2015
Author(s)
Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.2014
Author(s)
13.Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.da, T., Hirata, S., Takamatsu, K., Haruta, M., Tsukamoto, H., Ito, T., Uchino, M., Ando, Y., Nagafuchi, S., Nishimura, Y., Senju, S.
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Journal Title
PLoS One
Volume: 9
Issue: 12
Pages: e115198-e115198
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.2013
Author(s)
Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, Hamada H, Harada M, Shiokawa Y, Nishida T, Tominaga R, Kikushige Y, Akashi K, Kudoh J, Shimizu N, Tanaka Y, Umemura T, Taniguchi T, Yoshimura A, Kobayashi T, Mitsuyama M, Kurisaki H, Katsuta H, Nagafuchi S.
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Journal Title
Gene
Volume: 530
Pages: 19-25
Related Report
Peer Reviewed
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