| Project/Area Number |
25670462
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Keiko 東北大学, 大学院医学系研究科, 准教授 (00291253)
TAKAMI Seiichi 東北大学, 多元物質科学研究所, 准教授 (40311550)
TOGASHI Takanari 山形大学, 理学部, 研究支援者 (80510122)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノ粒子ワクチン / ナノ粒子 / ワクチン / 結核 |
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| Outline of Final Research Achievements |
Tuberculosis is still an important health problem in the world, and development of a more effective vaccine has been desired. Recently, a novel approach using a nanoparticle technology has been conducted for development of vaccine. In this study, we performed a basic investigation to develop a new vaccine using magnetite nanoparticles. We succeeded in binding green fluorescence protein (GFP) to magnetite nanoparticles by introducing tandemly-arranged 6 arginines into this protein. In addition, we demonstrated that GFP-bound nanoparticles were incorporated by dendritic cells in the lungs of mice after intratracheal inoculation, which led to the immune response to this protein. Development of a novel vaccine may be expected by introducing vaccine antigen into the magnetite nanoparticles.
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