| Project/Area Number |
25670469
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Kazuaki 北里大学, 北里生命科学研究所, 研究員 (30547386)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Hidenori 北里大学, 大学院感染制御科学府, 講師 (30219373)
YOSHIDA Haruno 北里大学, 大学院感染制御科学府, 助手 (70563386)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細菌 / 侵襲性感染症 / 細胞間透過 / ゲノム / 病原因子 / 宿主因子 |
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| Outline of Final Research Achievements |
We selected high-virulent and low-virulent Group A streptococcal strains through the database concerning patients and pathogen characteristics, experiment assessing host intercellular translocation, and experiment using human CD46-transgenic mice, in order to clarify the pathological conditions of invasive streptococcal infections. As compared with those of the low-virulent strain, there were significant virulence factor (substitution of rocA gene) and host factor (up-regulation of Gstp1 gene expression), which contributed to host intercellular translocation of the high-virulent strain.
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