Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections
Project/Area Number |
25670469
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Kitasato University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ARAI Kazuaki 北里大学, 北里生命科学研究所, 研究員 (30547386)
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Co-Investigator(Renkei-kenkyūsha) |
MATSUI Hidenori 北里大学, 大学院感染制御科学府, 講師 (30219373)
YOSHIDA Haruno 北里大学, 大学院感染制御科学府, 助手 (70563386)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 細菌 / 侵襲性感染症 / 細胞間透過 / ゲノム / 病原因子 / 宿主因子 |
Outline of Final Research Achievements |
We selected high-virulent and low-virulent Group A streptococcal strains through the database concerning patients and pathogen characteristics, experiment assessing host intercellular translocation, and experiment using human CD46-transgenic mice, in order to clarify the pathological conditions of invasive streptococcal infections. As compared with those of the low-virulent strain, there were significant virulence factor (substitution of rocA gene) and host factor (up-regulation of Gstp1 gene expression), which contributed to host intercellular translocation of the high-virulent strain.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Severe Acute Otitis Media Caused by Mucoid<i> Streptococcus Pyogenes</i> in a Previously Healthy Adult2014
Author(s)
Risako Kakuta, Hisakazu Yano, Hiroshi Hidaka, Hiromitsu Miyazaki, Mihoko Irimada, Kiyoshi Oda, Kazuaki Arai, Daiki Ozawa,Takashi Takahashi, Mitsuo Kaku and Yukio Katori
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 232
Issue: 4
Pages: 301-304
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed
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