A basic study on combination vaccines of rotavirus and norovirus
| Project/Area Number |
25670479
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKITSU Shoko 東京大学, 医学系研究科, 客員研究員 (10082215)
TAKANASHI Sayaka 東京大学, 医学系研究科, 助教 (20645709)
MACHIDA Sanae 埼玉医科大学, 医学部, 助教 (00219362)
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| Research Collaborator |
KHAMRIN Pattara 日本大学, 医学部, 客員研究員
THONPRACHUM Aksara 日本学術振興会, 日本大学医学部, 外国人特別研究員
NOMURA Akiko イムノプローブ株式会社, 研究員
HAYAKAWA Satoshi 日本大学, 医学部, 教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ワクチン / ロタウイルス / ノロウイルス / 混合ワクチン / マウスモデル / 経口接種 / 皮下接種 / 経鼻接種 / マウス実験 / 経口投与 / 動物実験 |
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| Outline of Final Research Achievements |
Basic experiments was done for combination oral vaccines of rotavirus and norovirus. Rotavirus vaccine strain (Rotarix) and artificially produced rotavirus protein (VP6) were used for rotavirus vaccines. Virus like particles were used for norovirus vaccine. Elevation of viral antibodies was the same as the individual vaccine and a synergistic effect of combination vaccines were not recognized. Rotavirus gastroenteritis (diarrhea) was induced into newborn mice by oral vaccination. However norovirus gastroenteritis was not induced in newborn mice.
Combination vaccines are expected to develop in reference to the cases of rotavirus vaccination and the cases of recurrent norovirus infection.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Blood group substances as potential therapeutic agents for the prevention and treatment of infection with norovirusese proving novel binding patterns in human tissues.2014
Author(s)
Yazawa S, Yokobori T, Ueta G, Ide M, Altan B, Thongprachum A, Nishimura T, Nakajima T, Kominato Y, Asao T, Saniabadi AR, Furukawa K, Kuwano H, Pendu JL, Ushijima H
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Journal Title
Related Report
Peer Reviewed
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