| Project/Area Number |
25670483
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KASHIWAKURA Jun-ichi 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90373290)
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| Research Collaborator |
KAWAKAMI Toshiaki 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (60143418)
ANDO Tomoaki 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (10724669)
TAKEMORI TOSHITAda 独立行政法人理化学研究所, 統合生命医科学研究センター, 基盤ユニットリーダー (60114295)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヒスタミン遊離因子（HRF) / 食物アレルギー / マスト細胞 / HRF反応性IgE / 急速経口免疫療法(ROIT) / ヒスタミン遊離因子(HRF) / IgE / 高親和性IgE受容体 |
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| Outline of Final Research Achievements |
Histamine-releasing factor (HRF) plays a pro-inflammatory role in IgE-dependent anaphylaxis and airway inflammation (animal model of bronchial asthma). However, it is unknown whether HRF is involved in food allergy. Here we showed that HRF inhibitor-treated mice had reduced diarrhea occurrence in allergen-sensitized mice, suggesting that HRF is required for a full inflammatory response in food allergy. HRF-reactive IgE and IgG were increased in both food allergy patients and mouse models. Levels of HRF-reactive IgG in rash oral immune tolerance-induced patients were reduced, implying that HRF-reactive IgE and IgG may serve as a new biomarker for food allergy diagnosis and evaluation.
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