An application of imaging mass spectrometry to the analysis of human placental villous structure –In search of etiology-specific biopolymer-
| Project/Area Number |
25670490
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
HIROAKI ITOH 浜松医科大学, 医学部附属病院, 教授 (70263085)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Kazunao 浜松医科大学, 医学部附属病院, 講師 (50456571)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAYASAKA Takahiro 浜松医科大学, 医学部, 助教 (90415927)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 胎盤 / 質量顕微鏡法 / 妊娠 / 胎児発育不全 / 妊娠高血圧症候群 / 絨毛 / 病理 / 光学顕微鏡法 / リン脂質 / 質量顕微鏡 / 病理所見 / 胎児 / 母体 / 生体高分子 / 質量分析 |
|---|
| Outline of Final Research Achievements |
A matrix-assisted laser desorption ionization (MALDI)-based mass spectrometer provides clear two-dimensional molecular identification with highly sensitive mass spectrometry from mixtures of ions generated on tissue surfaces. We applied this technology to the molecular identification of phospholipids in the human term placenta and found that placental some of pathological findings were associated with the distribution pattern of sphingomyelin (d18:1/16:0) and phosphatidylcholine (16:0/20:4) in stem and terminal villi. The findings suggested that these biopolymers may be involved in the maintenance and/or pathological changes placental villus structures.
|
Report
(4 results)
Research Products
(15 results)
-
-
[Journal Article] Multiple pregnancy,short cervix, part-time worker, steroid use, low educational level, and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study.2014
Author(s)
Shiozaki, A., Yoneda S., Nakabayashi M., Takeda Y., Takeda S., Sugimura M., Yoshida K., Tajima A., Manabe M., Akagi K., Nakagawa S., Tada K., Imafuku N., Ogawa M., Mizunoe T., Kanayama N., Itoh H., Minoura S., Ogino M., Saito S.
-
Journal Title
J Obstet Gynaecol Res.
Volume: 40
Issue: 1
Pages: 53-61
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero2013
Author(s)
Y.K. Kohmura, N. Kanayama, K. Muramatsu, N. Tamura, C. Yaguchi, T. Uchida, K. Suzuki, K. Sugihara, S. Aoe, T. Sasaki, T. Suganami, Y. Ogawa, H. Itoh
-
Journal Title
Reprod. Sci.
Volume: 20
Issue: 7
Pages: 813-827
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
