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Contribution of mitochondrioa to keratinization

Research Project

Project/Area Number 25670495
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

ABE Riichiro  北海道大学, 医学(系)研究科(研究院), 准教授 (60344511)

Co-Investigator(Kenkyū-buntansha) FUJITA Yasuyuki  北海道大学, 北海道大学病院, 助教 (80374437)
Co-Investigator(Renkei-kenkyūsha) SUTO Asuka  北海道大学, 医学研究科, 大学院生
Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsミトコンドリア / 角化
Research Abstract

Mitochondria play critical roles in many cellular processes, including cell death. Recently, it is reported that mitochondrial fission/fusion processes are important for cell death. Mitochondrial morphologies are regulated by several GTPases: fusion is mediated by mitofusin 1 (Mfn1) and Mfn2. Proper mitochondrial dynamics are critical for human health.
Keratinization requires strict regulation of keratinocyte proliferation and cell death. However, the role of mitochondria in keratinization remains obscure. We showed that mitochondria in keratinocyte cells were distributed in the perinuclear regions. No difference in mitochondrial morphology between the basal and the suprabasal cells. However, the number of mitochondria per cell was significantly higher in the suprabasal cells than in the basal cells. We found that the expression patterns of Mfn1 and Mfn2 were quite different: Mfn1 was expressed in the suprabasal cells, whereas Mfn2 was expressed only in the basal cells.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] The mitochondria fusion proteins Mfn1 and Mfn2 are involved in keratinization2013

    • Author(s)
      Asuka Suto, Riichiro Abe
    • Organizer
      The 4th international Symposium on Dynamics of Mitochondria
    • Place of Presentation
      Okinawa Zanpamisaki Royal Hotel (Yomitan Village)
    • Related Report
      2013 Final Research Report
  • [Presentation] The mitochondrial fusion proteins Mfn1 and Mfn2 are involved in keratinocytes2013

    • Author(s)
      Asuka Suto
    • Organizer
      The 4th INternational Symposium on Dynamics of Mitochondria
    • Place of Presentation
      Okinawa Zanpamisaki Royal Hotel(Yomitan Village)
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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