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Establishment of two-person neuroscience and its application to psychiatry

Research Project

Project/Area Number 25670509
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

Fukuda Masato  群馬大学, 医学(系)研究科(研究院), 教授 (20221533)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Keisuke  群馬大学, 大学院医学系研究科, 助教 (20455984)
TAKEI Yuichi  群馬大学, 大学院医学系研究科, 講師 (30455985)
NARITA Kosuke  群馬大学, 大学院医学系研究科, 講師 (70345677)
AOYAMA Yoshiyuki  群馬大学, 大学院医学系研究科, 助教 (60568351)
SUDA Masashi  群馬大学, 大学院医学系研究科, 助教 (30553747)
FUJIHIRA Kazuyoshi  群馬大学, 大学院医学系研究科, 助教 (70625582)
HATTORI Suguru  群馬大学, 大学院医学系研究科, 助教 (30241897)
FUJIHARA Kazuyuki  群馬大学, 大学院医学系研究科, 助教 (20735154)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脳 / 精神 / 精神疾患 / 脳機能画像 / 近赤外線スペクトロスコピィ / 実世界 / 複数個体 / 対人関係 / 脳・神経 / 脳神経疾患
Outline of Final Research Achievements

Interpersonal relationship is one of the fundamental daily activities of human beings as social entities. Brain substrates of such interpersonal relationship were investigated by recording brain functions just during real conversations between two persons. Obtained brain activities corresponded to personality features in healthy subjects and clinical symptoms in psychiatric disorders. These findings lead to a pioneering science field “two-person neuroscience” through “real-world neuroimaging”.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (52 results)

All 2016 2015 2014 2013 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 4 results,  Acknowledgement Compliant: 7 results) Presentation (21 results) (of which Invited: 5 results) Book (15 results)

  • [Journal Article] The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: a multimodal-imaging study using MEG and MRS2016

    • Author(s)
      Takei Y, Fujihara K, Tagawa M, Hironaga N, Near J, Kasagi M, Takahashi Y, Motegi T, Suzuki Y, Aoyama Y, Sakurai N, Yamaguchi M, Tobimatsu S, Ujita K, Tsushima Y, Narita K, Fukuda M
    • Journal Title

      NeuroImage

      Volume: 印刷中 Pages: 302-315

    • DOI

      10.1016/j.neuroimage.2015.12.057

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Blood transcriptomic markers in patients with late-onset major depressive disorder2016

    • Author(s)
      Miyata S, Kurachi M, Okano Y, Sakurai N, Kobayashi A, Harada K, Yamagata H, Matsuo K, Takahashi K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0150262-e0150262

    • DOI

      10.1371/journal.pone.0150262

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia.2016

    • Author(s)
      Araki T, Kirihara K, Koshiyama D, Nagai T, Tada M, Fukuda M, Kasai K
    • Journal Title

      Psychiatry Clin Neurosci,

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A concurrent fNIRS-fMRI measurement for validation of a separation method between deep and shallow fNIRS signals with multi-distance optodes.2015

    • Author(s)
      Tsukasa Funane, Hiroki Sato, Noriaki Yahata, Ryu Takizawa, et al.
    • Journal Title

      Neurophotonics

      Volume: 2(1) Issue: 1 Pages: 015003-015003

    • DOI

      10.1117/1.nph.2.1.015003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task.2015

    • Author(s)
      Fujihara K, Narita K, Suzuki Y, Takei Y, Suda M, Tagawa M, Ujita K, Sakai Y, Narumoto J, Near J, Fukuda M.
    • Journal Title

      Neuroimage

      Volume: 109 Pages: 102-8

    • DOI

      10.1016/j.neuroimage.2015.01.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A magnetoencephalography study of the effect of attention modulation on somatosensory processing in patients with major depressive disorder.2015

    • Author(s)
      Kurita S, Takei Y, Maki Y, Hattori S, Uehara T, Fukuda M, Mikuni M
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 70 Issue: 2 Pages: 116-125

    • DOI

      10.1111/pcn.12361

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Concurrent fNIRS-fMRI measurement to validate a method for separating deep and shallow fNIRS signals by using multidistance optodes2015

    • Author(s)
      Funane T, Sato H, Yahata N, Takizawa R, Nishimura Y, Kinoshita A, Katura T, Atsumori H, Fukuda M, Kasai K, Koizumi H, Kiguchi M
    • Journal Title

      Neurophotonics

      Volume: 2 Pages: 015003-015003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 「抑うつ状態の鑑別診断補助」としての光トポグラフィー検査 ―精神疾患の臨床検査を保険診療として実用化する意義2015

    • Author(s)
      福田正人
    • Journal Title

      精神神経学雑誌

      Volume: 117 Pages: 79-93

    • NAID

      40020375980

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The future of real-world neuroscience: imaging techniques to assess active brains in social environments2014

    • Author(s)
      Kasai K, Fukuda M, Yahata N, Morita K, Fujii N
    • Journal Title

      Neurosci Res

      Volume: 90 Pages: 65-71

    • DOI

      10.1016/j.neures.2014.11.007

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder2014

    • Author(s)
      Takei Y, Suda M, Aoyama Y, Sakurai N, Tagawa M, Motegi T, Yamaguchi M, Narita K, Fukuda
    • Journal Title

      J Psychiatr Res

      Volume: 57 Pages: 74-83

    • DOI

      10.1016/j.jpsychires.2014.06.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Kasai K (in press) Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia2014

    • Author(s)
      Marumo K, Takizawa R, Kinou M,Kawasaki S, Kawakubo Y, Fukuda M
    • Journal Title

      NeuroImage, in press

      Volume: 85 Pages: 518-526

    • DOI

      10.1016/j.neuroimage.2013.04.050

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuroimaging-aided differential diagnosis of the depressive state2014

    • Author(s)
      Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa S, Okazaki Y; Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group.
    • Journal Title

      Neuroimage

      Volume: 85 Pages: 498-507

    • DOI

      10.1016/j.neuroimage.2013.05.126

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression.2013

    • Author(s)
      Kinou M, Takizawa R, Marumo K, Kawasaki S, Kawakubo Y, Fukuda M, Kasai K
    • Journal Title

      Schizophr Res

      Volume: 150 Issue: 2-3 Pages: 459-67

    • DOI

      10.1016/j.schres.2013.08.026

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A NIRS–fMRI investigation of prefrontal cortex activity during a working memory task.2013

    • Author(s)
      Sato H, Yahata N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K
    • Journal Title

      Neuroimage

      Volume: 83 Pages: 158-73

    • DOI

      10.1016/j.neuroimage.2013.06.043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study2013

    • Author(s)
      Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
    • Journal Title

      J Psychiat Res

      Volume: 47 Issue: 11 Pages: 1581-9

    • DOI

      10.1016/j.jpsychires.2013.07.029

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2013)臨床神経生理学から見た精神疾患の病態生理.精神経誌:.2013

    • Author(s)
      福田正人
    • Journal Title

      精神神経学雑誌

      Volume: 115 Pages: 187-193

    • Related Report
      2013 Research-status Report
  • [Presentation] 脳磁図を用いた精神疾患の安静時神経ネットワークの研究2016

    • Author(s)
      田川みなみ,武井雄一,藤原和之,山口実穂,笠木真人,鈴木雄介,茂木智和,高橋由美子,成田耕介,加藤隆,齊藤良,福田正人
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      ベイシア文化ホール(群馬県前橋市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 前部帯状回のGABA 濃度と帯状回領域内の安静時機能的結合強度の関連2015

    • Author(s)
      藤原和之,成田耕介,鈴木雄介,笠木真人,茂木智和,武井雄一,田川みなみ,氏田浩一,対馬義人, Near Jamie,福田正人
    • Organizer
      第44回日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] パニック障害患者における認知行動療法の効果 :NIRS を用いた縦断的検討2015

    • Author(s)
      小野樹郎,武井雄一,三浦あやか,林若穂,平野かほり,櫻井敬子,高嶺朋三,村山侑里,青山義之,成田耕介,福田正人
    • Organizer
      第44回日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 興奮-抑制バランスはワーキングメモリー課題におけるオシレーション変化を予測する2015

    • Author(s)
      武井雄一,藤原和之,田川みなみ,廣永成人,笠木真人,高橋由美子,茂木智和,鈴木雄介,青山義之, 櫻井敬子,山口実穂,飛松省三,氏田浩一,対馬義人,成田耕介,福田正人
    • Organizer
      第44回日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 双極性障害における空間再認記憶の障害と白質統合性の関連2015

    • Author(s)
      藤原和之,成田耕介,武井雄一,須田真史,青山義之,氏田浩一,福田正人
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      タワーホール船橋(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 精神疾患の客観的補助診断法-NIRSの経験から2015

    • Author(s)
      福田正人,武井雄一,青山義之,櫻井敬子,小野樹郎,成田秀幸,成田耕介
    • Organizer
      第37回 日本生物学的精神医学会
    • Place of Presentation
      タワーホール船橋(東京都江戸川区)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] -Aminobutyric acid in anterior cingulate cortex predicts intra-cingulum functional connectivity in human:a magnetic resonance imaging study.2015

    • Author(s)
      藤原和之,成田耕介,鈴木雄介,笠木真人,茂木智和,武井雄一,田川みなみ,氏田浩一,Jamie Near,福田正人
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 近赤外線スペクトロスコピィー(NIRS)を用いた広汎性発達障害の前頭葉機能についての検討2015

    • Author(s)
      佐藤利正,成田秀幸,武井雄一,須田真史,桜井敬子,山口実穂,成田耕介,福田正人,三國雅彦
    • Organizer
      第18回 日本光脳機能イメージング学会
    • Place of Presentation
      星陵会館(東京都千代田区)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 臨床ユーザーが考えるNIRSにできないこと2015

    • Author(s)
      福田正人
    • Organizer
      第17回 日本ヒト脳機能マッピング学会
    • Place of Presentation
      毎日新聞オーバルホール(大阪府大阪市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of the rat depression model related to selective white matter injury: Possible aspect of depression related to selective white matter injury2014

    • Author(s)
      Ono H, Imai H, Miyawaki S, Miyata S, Nakatomi H, Mikuni M, Fukuda M, Saito N
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Identical blood biomarkers in late-onset major depressive disorder patients and model mice.2014

    • Author(s)
      Miyata S, Kurachi, M, Sakurai N, Takahashi K, Yamagata H, Matsuo K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] The relationship between neurotransmitters and neural oscillation during resting state : a combined magnetic resonance spectroscopy and magnetoencephalography study.2014

    • Author(s)
      Tagawa M, Takei Y, Fujihara K, Suzuki Y, Sakurai N, Kasagi M, Yamaguchi M, Motegi T, Aoyama Y, Narita K, Hironaga N, Ujita K, Tobimatsu S, Near J, Fukuda M
    • Organizer
      19th International Conference on Biomagnetism
    • Place of Presentation
      Halifax, Canada
    • Year and Date
      2014-08-24
    • Related Report
      2014 Research-status Report
  • [Presentation] The relationship between neurotransmitters and neural oscillation during working memory task: a combined magnetic resonance spectroscopy and magnetoencephalography study.2014

    • Author(s)
      Motegi T, Takei Y, Fujihara K, Suzuki Y, Aoyama Y, Sakurai N, Tagawa M, Yamaguchi M, Narita K, Hironaga S, Tobimatsu S, Near J, Fukuda M
    • Organizer
      19th International Conference on Biomagnetism
    • Place of Presentation
      Halifax, Canada
    • Year and Date
      2014-08-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Interactive brains in real-world: near-infrared studies of conversation2014

    • Author(s)
      Fukuda M, Takei Y, Suda M
    • Organizer
      BESETO 2014
    • Place of Presentation
      東京大学
    • Year and Date
      2014-07-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Real-world Neuroimaging in Psychiatry using Near-infrared Spectroscopy (Symposium 2: Cognition and Emotion in Schizophrenia and Mood Disorders: Findings from Lab and Real-World)

    • Author(s)
      Fukuda M, Suda M, Takei Y, Sakurai N, Yamaguchi M, Aoyama Y, Takahashi K, Narita K
    • Organizer
      The 15th Anniversary Meeting of Korean Society for Schizophrenia Research “New Horizons of Schizophrenia”
    • Place of Presentation
      Seoul
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Frontal lobe dysfunction in pervasive developmental disorder revealed by multichannel near-infrared spectroscopy (NIRS)

    • Author(s)
      Sato T, Narita H, Takei Y, Suda M, Sakurai N, Yamaguchi M, Narita K, Fukuda M, Mikuni M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] Two brain coherence during face-to-face conversation: near infrared spectroscopy study

    • Author(s)
      Suda M, Takei Y, Kawasaki S, Sakurai N, Narita K, Fukuda M, Mikuni M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] Hemodynamic changes of psychiatric diseases during a face-to-face conversation

    • Author(s)
      Takei Y, Suda M, Aoyama Y, Narita K, Sakurai N, Yamaguchi M, Kameyama M, Fukuda M, Mikuni M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] Real-world neuroimaging in psychiatry using near-infrared spectroscopy (Satellite Symposium SA-05: Schizophrenia as a disorder of adolescent mind and self-regulation)

    • Author(s)
      Fukuda, M
    • Organizer
      The 11th World Congress of Psychiatry
    • Place of Presentation
      kyoto
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Real-world neuroimagingしてのNIRSの意義

    • Author(s)
      福田正人
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 精神疾患についての臨床応用の現状(シンポジウム2:NIRSの最前線)

    • Author(s)
      福田正人,須田真史,武井雄一, 山口実穂,桜井敬子,成田耕介
    • Organizer
      第15回 日本ヒト脳機能マッピング学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 脳科学辞典2016

    • Author(s)
      福田正人
    • Publisher
      日本神経科学学会
    • Related Report
      2015 Annual Research Report
  • [Book] 薬物療法を精神病理学的視点から考え2015

    • Author(s)
      福田正人
    • Total Pages
      8
    • Publisher
      学樹書院
    • Related Report
      2015 Annual Research Report
  • [Book] 思春期学2015

    • Author(s)
      福田正人
    • Total Pages
      13
    • Publisher
      東京大学出版会
    • Related Report
      2015 Annual Research Report
  • [Book] 情動の仕組みとその異常2015

    • Author(s)
      福田正人,高橋啓介,武井雄一
    • Total Pages
      14
    • Publisher
      朝倉書店
    • Related Report
      2015 Annual Research Report
  • [Book] 外来で診る統合失調症2015

    • Author(s)
      福田正人
    • Total Pages
      9
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 統合失調症 In:山脇成人・西条寿夫 編『情動の仕組みとその異常』2015

    • Author(s)
      福田正人,高橋啓介
    • Publisher
      朝倉書店
    • Related Report
      2014 Research-status Report
  • [Book] 思春期における自我の確立とその脳基盤 In:笠井清登,長谷川眞理子,藤井直敬,福田正人 編『思春期学』2015

    • Author(s)
      福田正人
    • Publisher
      東京大学出版会
    • Related Report
      2014 Research-status Report
  • [Book] 臨床検査の有用性の現状とその意味 In:水野雅文 編『外来で診る統合失調症』2015

    • Author(s)
      福田正人
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 統合失調症の薬物療法の精神病理学的意義 In:石郷岡純・加藤敏編『薬物療法を精神病理学的視点から考える』2015

    • Author(s)
      福田正人
    • Publisher
      学樹書院
    • Related Report
      2014 Research-status Report
  • [Book] 診断概念の変遷-DSM-III以降(統合失調症スペクトラム障害および他の精神病性障害).In:村井俊哉・宮田久嗣 編『DSM-5を読み解く:伝統的精神病理,DSM-IV,ICD-10をふまえた新時代の精神科診断-統合失調症スペクトラム障害および他の精神病性障害,物質関連障害および嗜癖性障害群』2014

    • Author(s)
      福田正人,青山義之
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Book] 『精神疾患の脳画像ケースカンファレンス-診断と治療へのアプローチ』2014

    • Author(s)
      福田正人(監修)
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Book] Bipolar Disorder研究会『Bipolar Disorder 12』2014

    • Author(s)
      福田正人,須田真史,武井雄一,山口実穂,桜井敬子,成田耕介
    • Publisher
      アルタ出版
    • Related Report
      2014 Research-status Report
  • [Book] 発達精神病理としての統合失調症-脳と生活と言葉. In:福田正人,糸川昌成,村井俊哉,笠井清登編(2013)『統合失調症』2013

    • Author(s)
      福田正人
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] 『統合失調症』2013

    • Author(s)
      福田正人,糸川昌成,村井俊哉, 笠井清登
    • Total Pages
      753
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] In:山内俊雄・松田博史『脳画像でみる精神疾患』2013

    • Author(s)
      福田正人,須田真史,小池進介, 西村幸香,川久保友紀,野田隆政, 吉田寿美子
    • Publisher
      新興医学出版社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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