Establishment of two-person neuroscience and its application to psychiatry

• Project/Area Number: 25670509
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Gunma University
• Principal Investigator: Fukuda Masato 群馬大学, 医学(系)研究科(研究院), 教授 (20221533)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Keisuke 群馬大学, 大学院医学系研究科, 助教 (20455984) ; TAKEI Yuichi 群馬大学, 大学院医学系研究科, 講師 (30455985) ; NARITA Kosuke 群馬大学, 大学院医学系研究科, 講師 (70345677) ; AOYAMA Yoshiyuki 群馬大学, 大学院医学系研究科, 助教 (60568351) ; SUDA Masashi 群馬大学, 大学院医学系研究科, 助教 (30553747) ; FUJIHIRA Kazuyoshi 群馬大学, 大学院医学系研究科, 助教 (70625582) ; HATTORI Suguru 群馬大学, 大学院医学系研究科, 助教 (30241897) ; FUJIHARA Kazuyuki 群馬大学, 大学院医学系研究科, 助教 (20735154)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 脳 / 精神 / 精神疾患 / 脳機能画像 / 近赤外線スペクトロスコピィ / 実世界 / 複数個体 / 対人関係 / 脳・神経 / 脳神経疾患

Outline of Final Research Achievements

Interpersonal relationship is one of the fundamental daily activities of human beings as social entities. Brain substrates of such interpersonal relationship were investigated by recording brain functions just during real conversations between two persons. Obtained brain activities corresponded to personality features in healthy subjects and clinical symptoms in psychiatric disorders. These findings lead to a pioneering science field “two-person neuroscience” through “real-world neuroimaging”.

Research Products

• [Journal Article] The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: a multimodal-imaging study using MEG and MRS (2016)
  • Author(s): Takei Y, Fujihara K, Tagawa M, Hironaga N, Near J, Kasagi M, Takahashi Y, Motegi T, Suzuki Y, Aoyama Y, Sakurai N, Yamaguchi M, Tobimatsu S, Ujita K, Tsushima Y, Narita K, Fukuda M
  • Journal Title: NeuroImage Volume: 印刷中 Pages: 302-315
  • DOI: 10.1016/j.neuroimage.2015.12.057
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Blood transcriptomic markers in patients with late-onset major depressive disorder (2016)
  • Author(s): Miyata S, Kurachi M, Okano Y, Sakurai N, Kobayashi A, Harada K, Yamagata H, Matsuo K, Takahashi K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0150262-e0150262
  • DOI: 10.1371/journal.pone.0150262
  • Peer Reviewed / Open Access
• [Journal Article] Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia. (2016)
  • Author(s): Araki T, Kirihara K, Koshiyama D, Nagai T, Tada M, Fukuda M, Kasai K
  • Journal Title: Psychiatry Clin Neurosci, Volume: in press
  • Peer Reviewed
• [Journal Article] A concurrent fNIRS-fMRI measurement for validation of a separation method between deep and shallow fNIRS signals with multi-distance optodes. (2015)
  • Author(s): Tsukasa Funane, Hiroki Sato, Noriaki Yahata, Ryu Takizawa, et al.
  • Journal Title: Neurophotonics Volume: 2(1) Issue: 1 Pages: 015003-015003
  • DOI: 10.1117/1.nph.2.1.015003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task. (2015)
  • Author(s): Fujihara K, Narita K, Suzuki Y, Takei Y, Suda M, Tagawa M, Ujita K, Sakai Y, Narumoto J, Near J, Fukuda M.
  • Journal Title: Neuroimage Volume: 109 Pages: 102-8
  • DOI: 10.1016/j.neuroimage.2015.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A magnetoencephalography study of the effect of attention modulation on somatosensory processing in patients with major depressive disorder. (2015)
  • Author(s): Kurita S, Takei Y, Maki Y, Hattori S, Uehara T, Fukuda M, Mikuni M
  • Journal Title: Psychiatry Clin Neurosci Volume: 70 Issue: 2 Pages: 116-125
  • DOI: 10.1111/pcn.12361
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Concurrent fNIRS-fMRI measurement to validate a method for separating deep and shallow fNIRS signals by using multidistance optodes (2015)
  • Author(s): Funane T, Sato H, Yahata N, Takizawa R, Nishimura Y, Kinoshita A, Katura T, Atsumori H, Fukuda M, Kasai K, Koizumi H, Kiguchi M
  • Journal Title: Neurophotonics Volume: 2 Pages: 015003-015003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 「抑うつ状態の鑑別診断補助」としての光トポグラフィー検査 ―精神疾患の臨床検査を保険診療として実用化する意義 (2015)
  • Author(s): 福田正人
  • Journal Title: 精神神経学雑誌 Volume: 117 Pages: 79-93
  • NAID: 40020375980
  • Peer Reviewed
• [Journal Article] The future of real-world neuroscience: imaging techniques to assess active brains in social environments (2014)
  • Author(s): Kasai K, Fukuda M, Yahata N, Morita K, Fujii N
  • Journal Title: Neurosci Res Volume: 90 Pages: 65-71
  • DOI: 10.1016/j.neures.2014.11.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Near-infrared spectroscopic study of frontopolar activation during face-to-face conversation in major depressive disorder and bipolar disorder (2014)
  • Author(s): Takei Y, Suda M, Aoyama Y, Sakurai N, Tagawa M, Motegi T, Yamaguchi M, Narita K, Fukuda
  • Journal Title: J Psychiatr Res Volume: 57 Pages: 74-83
  • DOI: 10.1016/j.jpsychires.2014.06.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Kasai K (in press) Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia (2014)
  • Author(s): Marumo K, Takizawa R, Kinou M,Kawasaki S, Kawakubo Y, Fukuda M
  • Journal Title: NeuroImage, in press Volume: 85 Pages: 518-526
  • DOI: 10.1016/j.neuroimage.2013.04.050
  • Peer Reviewed
• [Journal Article] Neuroimaging-aided differential diagnosis of the depressive state (2014)
  • Author(s): Takizawa R, Fukuda M, Kawasaki S, Kasai K, Mimura M, Pu S, Noda T, Niwa S, Okazaki Y; Joint Project for Psychiatric Application of Near-Infrared Spectroscopy (JPSY-NIRS) Group.
  • Journal Title: Neuroimage Volume: 85 Pages: 498-507
  • DOI: 10.1016/j.neuroimage.2013.05.126
  • Peer Reviewed
• [Journal Article] Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression. (2013)
  • Author(s): Kinou M, Takizawa R, Marumo K, Kawasaki S, Kawakubo Y, Fukuda M, Kasai K
  • Journal Title: Schizophr Res Volume: 150 Issue: 2-3 Pages: 459-67
  • DOI: 10.1016/j.schres.2013.08.026
  • Peer Reviewed
• [Journal Article] A NIRS–fMRI investigation of prefrontal cortex activity during a working memory task. (2013)
  • Author(s): Sato H, Yahata N, Funane T, Takizawa R, Katura T, Atsumori H, Nishimura Y, Kinoshita A, Kiguchi M, Koizumi H, Fukuda M, Kasai K
  • Journal Title: Neuroimage Volume: 83 Pages: 158-73
  • DOI: 10.1016/j.neuroimage.2013.06.043
  • Peer Reviewed
• [Journal Article] Temporal lobe and inferior frontal gyrus dysfunction in patients with schizophrenia during face-to-face conversation: a near-infrared spectroscopy study (2013)
  • Author(s): Takei Y, Suda M, Aoyama Y, Yamaguchi M, Sakurai N, Narita K, Fukuda M, Mikuni M
  • Journal Title: J Psychiat Res Volume: 47 Issue: 11 Pages: 1581-9
  • DOI: 10.1016/j.jpsychires.2013.07.029
  • Peer Reviewed
• [Journal Article] 2013）臨床神経生理学から見た精神疾患の病態生理．精神経誌:. (2013)
  • Author(s): 福田正人
  • Journal Title: 精神神経学雑誌 Volume: 115 Pages: 187-193
• [Presentation] 脳磁図を用いた精神疾患の安静時神経ネットワークの研究 (2016)
  • Author(s): 田川みなみ，武井雄一，藤原和之，山口実穂，笠木真人，鈴木雄介，茂木智和，高橋由美子，成田耕介，加藤隆，齊藤良，福田正人
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2016-03-26
• [Presentation] 前部帯状回のGABA 濃度と帯状回領域内の安静時機能的結合強度の関連 (2015)
  • Author(s): 藤原和之，成田耕介，鈴木雄介，笠木真人，茂木智和，武井雄一，田川みなみ，氏田浩一，対馬義人， Near Jamie，福田正人
  • Organizer: 第44回日本臨床神経生理学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-11-07
• [Presentation] パニック障害患者における認知行動療法の効果 ：NIRS を用いた縦断的検討 (2015)
  • Author(s): 小野樹郎，武井雄一，三浦あやか，林若穂，平野かほり，櫻井敬子，高嶺朋三，村山侑里，青山義之，成田耕介，福田正人
  • Organizer: 第44回日本臨床神経生理学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-11-07
• [Presentation] 興奮-抑制バランスはワーキングメモリー課題におけるオシレーション変化を予測する (2015)
  • Author(s): 武井雄一，藤原和之，田川みなみ，廣永成人，笠木真人，高橋由美子，茂木智和，鈴木雄介，青山義之, 櫻井敬子，山口実穂，飛松省三，氏田浩一，対馬義人，成田耕介，福田正人
  • Organizer: 第44回日本臨床神経生理学会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-11-07
• [Presentation] 双極性障害における空間再認記憶の障害と白質統合性の関連 (2015)
  • Author(s): 藤原和之，成田耕介，武井雄一，須田真史，青山義之，氏田浩一，福田正人
  • Organizer: 第37回日本生物学的精神医学会
  • Place of Presentation: タワーホール船橋（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] 精神疾患の客観的補助診断法－NIRSの経験から (2015)
  • Author(s): 福田正人，武井雄一，青山義之，櫻井敬子，小野樹郎，成田秀幸，成田耕介
  • Organizer: 第37回 日本生物学的精神医学会
  • Place of Presentation: タワーホール船橋（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] -Aminobutyric acid in anterior cingulate cortex predicts intra-cingulum functional connectivity in human：a magnetic resonance imaging study. (2015)
  • Author(s): 藤原和之，成田耕介，鈴木雄介，笠木真人，茂木智和，武井雄一，田川みなみ，氏田浩一，Jamie Near，福田正人
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2015-09-11
• [Presentation] 近赤外線スペクトロスコピィー（NIRS）を用いた広汎性発達障害の前頭葉機能についての検討 (2015)
  • Author(s): 佐藤利正，成田秀幸，武井雄一，須田真史，桜井敬子，山口実穂，成田耕介，福田正人，三國雅彦
  • Organizer: 第18回 日本光脳機能イメージング学会
  • Place of Presentation: 星陵会館（東京都千代田区）
  • Year and Date: 2015-07-25
• [Presentation] 臨床ユーザーが考えるNIRSにできないこと (2015)
  • Author(s): 福田正人
  • Organizer: 第17回 日本ヒト脳機能マッピング学会
  • Place of Presentation: 毎日新聞オーバルホール（大阪府大阪市）
  • Year and Date: 2015-07-02
• [Presentation] Development of the rat depression model related to selective white matter injury: Possible aspect of depression related to selective white matter injury (2014)
  • Author(s): Ono H, Imai H, Miyawaki S, Miyata S, Nakatomi H, Mikuni M, Fukuda M, Saito N
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC
  • Year and Date: 2014-11-15
• [Presentation] Identical blood biomarkers in late-onset major depressive disorder patients and model mice. (2014)
  • Author(s): Miyata S, Kurachi, M, Sakurai N, Takahashi K, Yamagata H, Matsuo K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC
  • Year and Date: 2014-11-15
• [Presentation] The relationship between neurotransmitters and neural oscillation during resting state : a combined magnetic resonance spectroscopy and magnetoencephalography study. (2014)
  • Author(s): Tagawa M, Takei Y, Fujihara K, Suzuki Y, Sakurai N, Kasagi M, Yamaguchi M, Motegi T, Aoyama Y, Narita K, Hironaga N, Ujita K, Tobimatsu S, Near J, Fukuda M
  • Organizer: 19th International Conference on Biomagnetism
  • Place of Presentation: Halifax, Canada
  • Year and Date: 2014-08-24
• [Presentation] The relationship between neurotransmitters and neural oscillation during working memory task: a combined magnetic resonance spectroscopy and magnetoencephalography study. (2014)
  • Author(s): Motegi T, Takei Y, Fujihara K, Suzuki Y, Aoyama Y, Sakurai N, Tagawa M, Yamaguchi M, Narita K, Hironaga S, Tobimatsu S, Near J, Fukuda M
  • Organizer: 19th International Conference on Biomagnetism
  • Place of Presentation: Halifax, Canada
  • Year and Date: 2014-08-24
• [Presentation] Interactive brains in real-world: near-infrared studies of conversation (2014)
  • Author(s): Fukuda M, Takei Y, Suda M
  • Organizer: BESETO 2014
  • Place of Presentation: 東京大学
  • Year and Date: 2014-07-25
  • Invited
• [Presentation] Real-world Neuroimaging in Psychiatry using Near-infrared Spectroscopy (Symposium 2: Cognition and Emotion in Schizophrenia and Mood Disorders: Findings from Lab and Real-World)
  • Author(s): Fukuda M, Suda M, Takei Y, Sakurai N, Yamaguchi M, Aoyama Y, Takahashi K, Narita K
  • Organizer: The 15th Anniversary Meeting of Korean Society for Schizophrenia Research “New Horizons of Schizophrenia”
  • Place of Presentation: Seoul
  • Invited
• [Presentation] Frontal lobe dysfunction in pervasive developmental disorder revealed by multichannel near-infrared spectroscopy (NIRS)
  • Author(s): Sato T, Narita H, Takei Y, Suda M, Sakurai N, Yamaguchi M, Narita K, Fukuda M, Mikuni M
  • Organizer: The 11th World Congress of Psychiatry
  • Place of Presentation: kyoto
• [Presentation] Two brain coherence during face-to-face conversation: near infrared spectroscopy study
  • Author(s): Suda M, Takei Y, Kawasaki S, Sakurai N, Narita K, Fukuda M, Mikuni M
  • Organizer: The 11th World Congress of Psychiatry
  • Place of Presentation: kyoto
• [Presentation] Hemodynamic changes of psychiatric diseases during a face-to-face conversation
  • Author(s): Takei Y, Suda M, Aoyama Y, Narita K, Sakurai N, Yamaguchi M, Kameyama M, Fukuda M, Mikuni M
  • Organizer: The 11th World Congress of Psychiatry
  • Place of Presentation: kyoto
• [Presentation] Real-world neuroimaging in psychiatry using near-infrared spectroscopy (Satellite Symposium SA-05: Schizophrenia as a disorder of adolescent mind and self-regulation)
  • Author(s): Fukuda, M
  • Organizer: The 11th World Congress of Psychiatry
  • Place of Presentation: kyoto
  • Invited
• [Presentation] Real-world neuroimagingしてのNIRSの意義
  • Author(s): 福田正人
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
  • Invited
• [Presentation] 精神疾患についての臨床応用の現状（シンポジウム2：NIRSの最前線）
  • Author(s): 福田正人，須田真史，武井雄一， 山口実穂，桜井敬子，成田耕介
  • Organizer: 第15回 日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
  • Invited
• [Book] 脳科学辞典 (2016)
  • Author(s): 福田正人
  • Publisher: 日本神経科学学会
• [Book] 薬物療法を精神病理学的視点から考え (2015)
  • Author(s): 福田正人
  • Total Pages: 8
  • Publisher: 学樹書院
• [Book] 思春期学 (2015)
  • Author(s): 福田正人
  • Total Pages: 13
  • Publisher: 東京大学出版会
• [Book] 情動の仕組みとその異常 (2015)
  • Author(s): 福田正人，高橋啓介，武井雄一
  • Total Pages: 14
  • Publisher: 朝倉書店
• [Book] 外来で診る統合失調症 (2015)
  • Author(s): 福田正人
  • Total Pages: 9
  • Publisher: 医学書院
• [Book] 統合失調症 In：山脇成人・西条寿夫 編『情動の仕組みとその異常』 (2015)
  • Author(s): 福田正人，高橋啓介
  • Publisher: 朝倉書店
• [Book] 思春期における自我の確立とその脳基盤 In：笠井清登，長谷川眞理子，藤井直敬，福田正人 編『思春期学』 (2015)
  • Author(s): 福田正人
  • Publisher: 東京大学出版会
• [Book] 臨床検査の有用性の現状とその意味 In：水野雅文 編『外来で診る統合失調症』 (2015)
  • Author(s): 福田正人
  • Publisher: 医学書院
• [Book] 統合失調症の薬物療法の精神病理学的意義 In：石郷岡純・加藤敏編『薬物療法を精神病理学的視点から考える』 (2015)
  • Author(s): 福田正人
  • Publisher: 学樹書院
• [Book] 診断概念の変遷－DSM-III以降（統合失調症スペクトラム障害および他の精神病性障害）．In：村井俊哉・宮田久嗣 編『DSM-5を読み解く：伝統的精神病理，DSM-IV，ICD-10をふまえた新時代の精神科診断－統合失調症スペクトラム障害および他の精神病性障害，物質関連障害および嗜癖性障害群』 (2014)
  • Author(s): 福田正人，青山義之
  • Publisher: 中山書店
• [Book] 『精神疾患の脳画像ケースカンファレンス－診断と治療へのアプローチ』 (2014)
  • Author(s): 福田正人（監修）
  • Publisher: 中山書店
• [Book] Bipolar Disorder研究会『Bipolar Disorder 12』 (2014)
  • Author(s): 福田正人，須田真史，武井雄一，山口実穂，桜井敬子，成田耕介
  • Publisher: アルタ出版
• [Book] 発達精神病理としての統合失調症－脳と生活と言葉． In：福田正人，糸川昌成，村井俊哉，笠井清登編（2013）『統合失調症』 (2013)
  • Author(s): 福田正人
  • Publisher: 医学書院
• [Book] 『統合失調症』 (2013)
  • Author(s): 福田正人，糸川昌成，村井俊哉， 笠井清登
  • Total Pages: 753
  • Publisher: 医学書院
• [Book] In：山内俊雄・松田博史『脳画像でみる精神疾患』 (2013)
  • Author(s): 福田正人，須田真史，小池進介， 西村幸香，川久保友紀，野田隆政， 吉田寿美子
  • Publisher: 新興医学出版社