Grouping by brain network for tailor-made intervention of autism spectrum disorders
| Project/Area Number |
25670511
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自閉スペクトラム症 / 疫学研究 / 分子遺伝研究 / 脳イメージング / 拡散テンソル画像 / 自閉スペクトラム症(ASD) / 脳イメージング研究 / 分子遺伝学研究 / 脳磁図（MEG） / 自閉症スペクトラム障害 / 全エクソン解析 / 脳機能画像研究 / 脳磁図 / 脳画像研究 |
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| Outline of Final Research Achievements |
Rates of children with doubt of Autism spectrum disorder (ASD), in medical examination at the time of entering school, were 2.0% (45/2937) in Niigata city. As a risk factor of ASD, we identified a family history of mental disorders. In our imaging study using diffusion tensor imaging, we found a significant Fractional anisotropy (FA) decrease in thalamus-fornix region and increase in left middle cerebellar peduncle in the ASD group. “Switching of attention” score, which is a subscale score of Autism-spectrum Quotient (AQ), was correlated negatively with FA. In our molecular genetic study, to investigate the role of rare variations, we performed whole-exome sequencing (WES) with affected siblings. Ｗe identified rare risk candidate genes for ASD (2015 PLoS One; 2015 Psychiatry Res) .
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population.2016
Author(s)
Takasaki Y, Koide T, Wang C, Kimura H, Xing J, Kushima I, Ishizuka K, Mori D, Sekiguchi M, Ikeda M, Aizawa M, Tsurumaru N, Iwayama Y, Yoshimi A, Arioka Y, Yoshida M, Noma H, Oya-Ito T, Nakamura Y, Kunimoto S, Aleksic B, Uno Y, Okada T, Ujike H, Egawa J, Kuwabara H, Someya T, Yoshikawa T, Iwata N, Ozaki N
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 33311-33311
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel rare missense variations and risk of autism spectrum disorder: Whole-exome sequencing in two families with affected siblings and a two-stage follow-up study in a Japanese population.2015
Author(s)
Egawa J, Watanabe Y, Wang C, Inoue E, Sugimoto A, Sugiyama T, Igeta H, Nunokawa A, Shibuya M, Kushima I, Orime N, Hayashi T, Okada T, Uno Y, Ozaki N, Someya T
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Journal Title
PLoS One
Volume: 10(3)
Issue: 3
Pages: e0119413-e0119413
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxytocin receptor (OXTR) gene and risk of schizophrenia: Case-control and family-based analyses and meta-analysis in a Japanese population2012
Author(s)
Watanabe, Y., Kaneko, N., Nunokawa, A., Shibuya, M., Egawa, J., Someya, T.
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 66
Issue: 1
Pages: 622-622
DOI
Related Report
Peer Reviewed
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