Genetic screening of Japanese macaque aiming at discovery of primate models for psychiatric disorders
Project/Area Number |
25670516
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Nagoya University |
Principal Investigator |
OZAKI Norio 名古屋大学, 医学(系)研究科(研究院), 教授 (40281480)
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Co-Investigator(Renkei-kenkyūsha) |
IMAI Hiroo 京都大学, 霊長類研究所, 准教授 (60314176)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | ニホンザル / CNV / ゲノムコピー数変異 / 霊長類 / 精神疾患 / モデル動物 |
Outline of Final Research Achievements |
Recent genomic studies of psychiatric disorders have identified rare copy number variants (CNVs) with large effect size. In order to discover primate model for psychiatric disorders, we have performed genome-wide CNV screening in Japanese macaque. As a result, we detected CNVs overlapping neurodevelopmental genes including GRM5, NGF, BDNF, and ADORA2A. In particular, a duplication of ADORA2A region was previously implicated in psychiatric and neurodevelopmental disorders. Abnormal behaviors were not identified in one Japanese macaque with ADORA2A duplication, and a detailed phenotype analysis will be necessary in the future. In conclusion, we discovered candidates of primate model for psychiatric disorders, confirming the usefulness of CNV analyses for Japanese macaque.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.2015
Author(s)
Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 56
Pages: 11-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Resequencing and association analysis of PTPRA, a possible susceptibility gene for schizophrenia and autism spectrum disorders2014
Author(s)
Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N
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Journal Title
PLoS One
Volume: 9(11)
Issue: 11
Pages: e112531-e112531
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Resequencing and Association Analysis of PTPRA, a Possible Susceptibility Gene for Schizophrenia and Autism Spectrum Disorders2014
Author(s)
Xing J, Wang C, Kimura H, Takasaki Y, Kunimoto S, Yoshimi A, Nakamura Y, Koide T, Banno M, Kushima I, Uno Y, Okada T, Aleksic B, Ikeda M, Iwata N, Ozaki N.
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Journal Title
PLoS One
Volume: 9
Issue: 1-3
Pages: 149-156
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects.2014
Author(s)
Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Sasabayashi D, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 51
Pages: 166-171
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Common variants in bcl9 gene and schizophrenia in a japanese population: Association study, meta-analysis and cognitive function analysis.2013
Author(s)
Shiino T, Koide T, Kushima I, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Aleksic B, Banno M, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Okada T, Inada T, Ujike H, Iidaka T, Suzuki M, Iwata N, Ozaki N
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Journal Title
J Med Biochem
Volume: 32 (4)
Pages: 351-357
Related Report
Peer Reviewed
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[Journal Article] Definition and refinement of the 7q36.3 duplication region associated with schizophrenia2013
Author(s)
Aleksic B, Kushima I, Ohye T, Ikeda M, Kunimoto S, Nakamura Y, Yoshimi A, Koide T, Iritani S, Kurahashi H, Iwata N, Ozaki N
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Journal Title
Sci Rep
Volume: 3
Issue: 1
Pages: 2587-2587
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening.2012
Author(s)
Aleksic B, Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
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Journal Title
Schizophrenia Bulletin
Volume: 39
Issue: 3
Pages: 39-39
DOI
Related Report
Peer Reviewed