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The identification of biomarker for the circadian rhythm of clock gene of the bipolar disorder

Research Project

Project/Area Number 25670518
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Haga Toshiaki  聖マリアンナ医科大学, 医学部, 研究技術員 (80535625)

Co-Investigator(Kenkyū-buntansha) 長田 賢一  聖マリアンナ医科大学, 医学部, 准教授 (20233504)
貴家 康男  聖マリアンナ医科大学, 医学部, 講師 (60308450)
中野 三穂  聖マリアンナ医科大学, 医学部, 助教 (90621574)
Co-Investigator(Renkei-kenkyūsha) MATSUI Hiroaki  聖マリアンナ医科大学, 医学部, 教授 (90181685)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords時計遺伝子 / サーカディアンリズム
Outline of Final Research Achievements

Mental disorder caused by abnormality of the circadian rhythm of sleep-wake cycles has a many report. Above all, clock gene is important. We measured the mRNA expression of the clock gene from the hypothalamus and hippocampus which are central nervous system, and the submandibular gland which was a peripheral tissue. The clock gene developed in hypothalamus, hippocampus and submandibular glands and was found to form circadian rhythm in a period for 24 hours. Furthermore, the amplitude of the rhythm was more widely found in a peripheral tissue than central nervous system.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2014 2013

All Presentation (2 results)

  • [Presentation] The investigation of the circadian rhythm to mRNA clock gene from salivary glans cells2014

    • Author(s)
      芳賀俊明
    • Organizer
      第44回日本神経精神薬理学会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] The investigation of the circadian rhythm to mRNA clock gene from salivary glands cells2013

    • Author(s)
      芳賀俊明
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      アメリカ・サンディエゴ
    • Year and Date
      2013-11-12
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-03-29  

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