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Imaging glucose consumption in small structures in the human brain and cancer with a high resolution scanner

Research Project

Project/Area Number 25670525
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

TASHIRO Manabu  東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)

Co-Investigator(Renkei-kenkyūsha) Kikuchi Yohei  東北大学, 大学院工学研究科, 准教授 (50359535)
Yanai Kazuhiko  東北大学, 大学院医学系研究科, 教授 (50192787)
Hiraoka Kotaro  東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (70586049)
Watanuki Seiichi  東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (30210967)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsPET / 空間分解能 / 脳活動 / 筋活動 / 微小構造物 / ポジトロン放出断層法(PET) / 半導体PET / 脳微細構造機能イメージング / フルオロデオキシグルコース(FDG) / ポジトロン放出断層法 / フルオロデオキシグルコース(FDG)
Outline of Final Research Achievements

Purpose of this project was to evaluate the advantages of a new ultra-high resolution (1 mm or so) PET scanner with semiconductor detectors for humans.
The imaging results suggested that there were certain technical problems such as scatter correction and basic design of detectors and scanner gantry, showing the need of redesigning and reconstructing the scanner. In stead, the investigator evaluated the advantages of high resolution scanner using a scanner with relatively high resolution (2 mm or so). The results of imaging suggested a high resolution scanner is better for imaging small structures in the human body.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2016 2015 2014 2013

All Journal Article (25 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 24 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers.2016

    • Author(s)
      Inami A, Matsuda R, Grobosch T, Komamura H, Takeda K, Yamada Y, Miyake M, Hiraoka K, Maurer M, Yanai K, Tashiro M.
    • Journal Title

      Hum Psychopharmacol.

      Volume: Epub ahead of print Issue: 3 Pages: 167-77

    • DOI

      10.1002/hup.2524

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards.2016

    • Author(s)
      Sato K, Shidahara M, Watabe H, Watanuki S, Ishikawa Y, Arakawa Y, Nai YH, Furumoto S, Tashiro M, Shoji T, Yanai K, Gonda K.
    • Journal Title

      Phys Med Biol

      Volume: 61 Issue: 2 Pages: 696-711

    • DOI

      10.1088/0031-9155/61/2/696

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease2016

    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
    • Journal Title

      J Nucl Med

      Volume: 57 Issue: 2 Pages: 208-214

    • DOI

      10.2967/jnumed.115.164848

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and prognosis of prodromal Alzheimer's disease as assessed by magnetic resonance imaging and (18) F-fluorodeoxyglucose-positron emission tomography in a community: reanalysis from the Osaki-Tajiri Project.2016

    • Author(s)
      Meguro K, Akanuma K, Meguro M, Yamaguchi S, Ishii H, Tashiro M.
    • Journal Title

      Psychogeriatrics.

      Volume: 16(2) Issue: 2 Pages: 116-120

    • DOI

      10.1111/psyg.12131

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M. Singing can improve speech function in aphasics associated with intact right basal ganglia and preserve right temporal glucose metabolism: Implications for singing therapy indication.2016

    • Author(s)
      Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M.
    • Journal Title

      Int J Neurosci.

      Volume: 126(1) Issue: 1 Pages: 39-45

    • DOI

      10.3109/00207454.2014.992068

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography2015

    • Author(s)
      Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0140311

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histamine H receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers2015

    • Author(s)
      Sato, Hirotoshi Ito, Chihiro Hiraoka, Kotaro Tashiro, Manabu Shibuya, Katsuhiko Funaki, Yoshihito Yoshikawa, Takeo Iwata, Ren Matsuoka, Hiroo Yanai, Kazuhiko
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 232 Issue: 19 Pages: 3497-3505

    • DOI

      10.1007/s00213-015-4002-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus2015

    • Author(s)
      Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
    • Journal Title

      J Neurol Sci

      Volume: 356 Issue: 1-2 Pages: 124-128

    • DOI

      10.1016/j.jns.2015.06.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain.2015

    • Author(s)
      Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
    • Journal Title

      Nucl Med Biol.

      Volume: 42 Issue: 9 Pages: 734-744

    • DOI

      10.1016/j.nucmedbio.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015

    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Issue: 2 Pages: 199-206

    • DOI

      10.1517/14740338.2015.989831

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2015

    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 1 Pages: 1-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Singing can improve speech function in aphasics associated with intact right basal ganglia and preserved right temporal glucose metabolism: Implications for singing therapy indication.2015

    • Author(s)
      Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M.
    • Journal Title

      Int J Neurosci.

      Volume: 7 Pages: 1-16

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015

    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Pages: 199-206

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2014

    • Author(s)
      Harada R, Furukawa K, et al.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 42 Issue: 7 Pages: 1052-1061

    • DOI

      10.1007/s00259-015-3035-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.2014

    • Author(s)
      Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 234 Pages: 175-181

    • NAID

      130004694506

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "memory of food is impaired in dementia and responsible for poor diet".2014

    • Author(s)
      Suto T, Meguro K, Nakatsuka M, Kato Y, Tezuka K, Yamaguchi S, Tashiro M.
    • Journal Title

      Int Psychogeriatr.

      Volume: 26 Issue: 7 Pages: 1127-1138

    • DOI

      10.1017/s1041610214000532

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscle activity pattern of the shoulder external rotators differs in adduction and abduction: an analysis using positron emission tomography.2014

    • Author(s)
      Kurokawa D, Sano H, Nagamoto H, Omi R, Shinozaki N, Watanuki S, Kishimoto KN, Yamamoto N, Hiraoka K, Tashiro M, Itoi E.
    • Journal Title

      J Shoulder Elbow Surg.

      Volume: 23 Issue: 5 Pages: 658-664

    • DOI

      10.1016/j.jse.2013.12.021

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study.2014

    • Author(s)
      Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 15 Issue: 6 Pages: 666-672

    • DOI

      10.1093/ehjci/jet276

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis2014

    • Author(s)
      Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
    • Journal Title

      Jpn J Radiol

      Volume: 32 Issue: 3 Pages: 138-144

    • DOI

      10.1007/s11604-013-0276-7

    • NAID

      50009030775

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in muscle activities during shoulder elevation in patients with symptomatic and asymptomatic rotator cuff tears: analysis by positron emission tomography.2014

    • Author(s)
      Shinozaki N, Sano H, Omi R, Kishimoto KN, Yamamoto N, Tashiro M, Itoi E.
    • Journal Title

      J Shoulder Elbow Surg.

      Volume: 23 Issue: 3 Pages: e61-e67

    • DOI

      10.1016/j.jse.2013.06.009

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study.2014

    • Author(s)
      Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "Memory of food is impaired in dementia and responsible for poor diet".2014

    • Author(s)
      Suto T, Meguro K, Nakatsuka M, Kato Y, Tezuka K, Yamaguchi S, Tashiro M.
    • Journal Title

      Int Psychogeriatr.

      Volume: in press

    • Related Report
      2013 Research-status Report
  • [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans2013

    • Author(s)
      Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
    • Journal Title

      EJNMMI Res

      Volume: 3 Issue: 1 Pages: 32-32

    • DOI

      10.1186/2191-219x-3-32

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A ^<18>F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography2013

    • Author(s)
      Shozo Furumoto
    • Journal Title

      Molecular Imaging and Biology

      Volume: 15 Issue: 4 Pages: 497-506

    • DOI

      10.1007/s11307-012-0608-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine : a positron emission tomography study in healthy volunteers2013

    • Author(s)
      Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 230 (2) Issue: 2 Pages: 227-34

    • DOI

      10.1007/s00213-013-3146-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ポジトロン断層法および運転シミュレーターを用いた抗ヒスタミン薬の鎮静作用の評価2014

    • Author(s)
      田代学
    • Organizer
      皮膚免疫カンファレンス
    • Place of Presentation
      東京都港区
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ポジトロン断層法および運転シミュレーターを用いた抗ヒスタミン薬の鎮静作用の評価2014

    • Author(s)
      田代学
    • Organizer
      Science in Shinagawaセミナー
    • Place of Presentation
      東京都品川区
    • Year and Date
      2014-04-19
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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