Imaging glucose consumption in small structures in the human brain and cancer with a high resolution scanner

• Project/Area Number: 25670525
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
• Co-Investigator(Renkei-kenkyūsha): Kikuchi Yohei 東北大学, 大学院工学研究科, 准教授 (50359535) ; Yanai Kazuhiko 東北大学, 大学院医学系研究科, 教授 (50192787) ; Hiraoka Kotaro 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (70586049) ; Watanuki Seiichi 東北大学, サイクロトロン・ラジオアイソトープセンター, 助手 (30210967)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: PET / 空間分解能 / 脳活動 / 筋活動 / 微小構造物 / ポジトロン放出断層法（PET） / 半導体PET / 脳微細構造機能イメージング / フルオロデオキシグルコース（FDG） / ポジトロン放出断層法 / フルオロデオキシグルコース(FDG)

Outline of Final Research Achievements

Purpose of this project was to evaluate the advantages of a new ultra-high resolution (1 mm or so) PET scanner with semiconductor detectors for humans.
The imaging results suggested that there were certain technical problems such as scatter correction and basic design of detectors and scanner gantry, showing the need of redesigning and reconstructing the scanner. In stead, the investigator evaluated the advantages of high resolution scanner using a scanner with relatively high resolution (2 mm or so). The results of imaging suggested a high resolution scanner is better for imaging small structures in the human body.

Research Products

• [Journal Article] A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers. (2016)
  • Author(s): Inami A, Matsuda R, Grobosch T, Komamura H, Takeda K, Yamada Y, Miyake M, Hiraoka K, Maurer M, Yanai K, Tashiro M.
  • Journal Title: Hum Psychopharmacol. Volume: Epub ahead of print Issue: 3 Pages: 167-77
  • DOI: 10.1002/hup.2524
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards. (2016)
  • Author(s): Sato K, Shidahara M, Watabe H, Watanuki S, Ishikawa Y, Arakawa Y, Nai YH, Furumoto S, Tashiro M, Shoji T, Yanai K, Gonda K.
  • Journal Title: Phys Med Biol Volume: 61 Issue: 2 Pages: 696-711
  • DOI: 10.1088/0031-9155/61/2/696
  • Peer Reviewed
• [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease (2016)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
  • Journal Title: J Nucl Med Volume: 57 Issue: 2 Pages: 208-214
  • DOI: 10.2967/jnumed.115.164848
  • Peer Reviewed
• [Journal Article] Prevalence and prognosis of prodromal Alzheimer's disease as assessed by magnetic resonance imaging and (18) F-fluorodeoxyglucose-positron emission tomography in a community: reanalysis from the Osaki-Tajiri Project. (2016)
  • Author(s): Meguro K, Akanuma K, Meguro M, Yamaguchi S, Ishii H, Tashiro M.
  • Journal Title: Psychogeriatrics. Volume: 16(2) Issue: 2 Pages: 116-120
  • DOI: 10.1111/psyg.12131
  • Peer Reviewed
• [Journal Article] Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M. Singing can improve speech function in aphasics associated with intact right basal ganglia and preserve right temporal glucose metabolism: Implications for singing therapy indication. (2016)
  • Author(s): Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M.
  • Journal Title: Int J Neurosci. Volume: 126(1) Issue: 1 Pages: 39-45
  • DOI: 10.3109/00207454.2014.992068
  • Peer Reviewed
• [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography (2015)
  • Author(s): Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: 1-9
  • DOI: 10.1371/journal.pone.0140311
  • Peer Reviewed / Open Access
• [Journal Article] Histamine H receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers (2015)
  • Author(s): Sato, Hirotoshi Ito, Chihiro Hiraoka, Kotaro Tashiro, Manabu Shibuya, Katsuhiko Funaki, Yoshihito Yoshikawa, Takeo Iwata, Ren Matsuoka, Hiroo Yanai, Kazuhiko
  • Journal Title: Psychopharmacology (Berl) Volume: 232 Issue: 19 Pages: 3497-3505
  • DOI: 10.1007/s00213-015-4002-2
  • Peer Reviewed
• [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus (2015)
  • Author(s): Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
  • Journal Title: J Neurol Sci Volume: 356 Issue: 1-2 Pages: 124-128
  • DOI: 10.1016/j.jns.2015.06.029
  • Peer Reviewed
• [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain. (2015)
  • Author(s): Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
  • Journal Title: Nucl Med Biol. Volume: 42 Issue: 9 Pages: 734-744
  • DOI: 10.1016/j.nucmedbio.2015.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine. (2015)
  • Author(s): Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
  • Journal Title: Expert Opin Drug Saf. Volume: 14 Issue: 2 Pages: 199-206
  • DOI: 10.1517/14740338.2015.989831
  • Peer Reviewed / Open Access
• [Journal Article] [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. (2015)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 1 Pages: 1-2
  • Peer Reviewed
• [Journal Article] Singing can improve speech function in aphasics associated with intact right basal ganglia and preserved right temporal glucose metabolism: Implications for singing therapy indication. (2015)
  • Author(s): Akanuma K, Meguro K, Satoh M, Tashiro M, Itoh M.
  • Journal Title: Int J Neurosci. Volume: 7 Pages: 1-16
  • Peer Reviewed
• [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine. (2015)
  • Author(s): Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
  • Journal Title: Expert Opin Drug Saf. Volume: 14 Pages: 199-206
  • Peer Reviewed
• [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. (2014)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 42 Issue: 7 Pages: 1052-1061
  • DOI: 10.1007/s00259-015-3035-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull. (2014)
  • Author(s): Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
  • Journal Title: Tohoku J Exp Med. Volume: 234 Pages: 175-181
  • NAID: 130004694506
  • Peer Reviewed
• [Journal Article] Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "memory of food is impaired in dementia and responsible for poor diet". (2014)
  • Author(s): Suto T, Meguro K, Nakatsuka M, Kato Y, Tezuka K, Yamaguchi S, Tashiro M.
  • Journal Title: Int Psychogeriatr. Volume: 26 Issue: 7 Pages: 1127-1138
  • DOI: 10.1017/s1041610214000532
  • Peer Reviewed
• [Journal Article] Muscle activity pattern of the shoulder external rotators differs in adduction and abduction: an analysis using positron emission tomography. (2014)
  • Author(s): Kurokawa D, Sano H, Nagamoto H, Omi R, Shinozaki N, Watanuki S, Kishimoto KN, Yamamoto N, Hiraoka K, Tashiro M, Itoi E.
  • Journal Title: J Shoulder Elbow Surg. Volume: 23 Issue: 5 Pages: 658-664
  • DOI: 10.1016/j.jse.2013.12.021
  • Peer Reviewed
• [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study. (2014)
  • Author(s): Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 15 Issue: 6 Pages: 666-672
  • DOI: 10.1093/ehjci/jet276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
  • Journal Title: Jpn J Radiol Volume: 32 Issue: 3 Pages: 138-144
  • DOI: 10.1007/s11604-013-0276-7
  • NAID: 50009030775
  • Peer Reviewed / Open Access
• [Journal Article] Differences in muscle activities during shoulder elevation in patients with symptomatic and asymptomatic rotator cuff tears: analysis by positron emission tomography. (2014)
  • Author(s): Shinozaki N, Sano H, Omi R, Kishimoto KN, Yamamoto N, Tashiro M, Itoi E.
  • Journal Title: J Shoulder Elbow Surg. Volume: 23 Issue: 3 Pages: e61-e67
  • DOI: 10.1016/j.jse.2013.06.009
  • Peer Reviewed
• [Journal Article] Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: a preliminary observational study. (2014)
  • Author(s): Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: in press
  • Peer Reviewed
• [Journal Article] Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "Memory of food is impaired in dementia and responsible for poor diet". (2014)
  • Author(s): Suto T, Meguro K, Nakatsuka M, Kato Y, Tezuka K, Yamaguchi S, Tashiro M.
  • Journal Title: Int Psychogeriatr. Volume: in press
• [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans (2013)
  • Author(s): Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
  • Journal Title: EJNMMI Res Volume: 3 Issue: 1 Pages: 32-32
  • DOI: 10.1186/2191-219x-3-32
  • Peer Reviewed
• [Journal Article] A ^<18>F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography (2013)
  • Author(s): Shozo Furumoto
  • Journal Title: Molecular Imaging and Biology Volume: 15 Issue: 4 Pages: 497-506
  • DOI: 10.1007/s11307-012-0608-5
  • Peer Reviewed
• [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine : a positron emission tomography study in healthy volunteers (2013)
  • Author(s): Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
  • Journal Title: Psychopharmacology (Berl) Volume: 230 (2) Issue: 2 Pages: 227-34
  • DOI: 10.1007/s00213-013-3146-1
  • Peer Reviewed
• [Presentation] ポジトロン断層法および運転シミュレーターを用いた抗ヒスタミン薬の鎮静作用の評価 (2014)
  • Author(s): 田代学
  • Organizer: 皮膚免疫カンファレンス
  • Place of Presentation: 東京都港区
  • Year and Date: 2014-07-19 – 2014-07-20
  • Invited
• [Presentation] ポジトロン断層法および運転シミュレーターを用いた抗ヒスタミン薬の鎮静作用の評価 (2014)
  • Author(s): 田代学
  • Organizer: Science in Shinagawaセミナー
  • Place of Presentation: 東京都品川区
  • Year and Date: 2014-04-19
  • Invited