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Development of a new method for quantifying chemical exchange rate and visualizing pH using CEST MRI

Research Project

Project/Area Number 25670532
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

MURASE Kenya  大阪大学, 医学(系)研究科(研究院), 教授 (50157773)

Co-Investigator(Kenkyū-buntansha) YOSHIOKA Yoshichika  大阪大学, 免疫学フロンティア研究センター, 特任教授 (00174897)
KIMURA Atsuomi  大阪大学, 医学系研究科, 准教授 (70303972)
Research Collaborator TAKATA Hiroshige  
TAKEUCHI Yuki  
UEDA Junpei  
SASAHARA Hisato  
YABATA Isamu  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords化学交換飽和移動 / 核磁気共鳴撮像法 / pH / コンピュータシミュレーション / 化学交換速度 / 核磁気共鳴 / 水素イオン指数 / pH
Outline of Final Research Achievements

Recently, magnetic resonance imaging (MRI) using chemical exchange saturation transfer (CEST) phenomenon (CEST MRI) was developed, and its clinical application is expected as a new molecular imaging technique. In this research project, we proposed a new method for quantifying the chemical exchange rate and for imaging pH using CEST MRI and investigated the precision and reliability of our proposed method by computer simulation and phantom experiments. As a result, we found that our method was superior to the conventional method in terms of the precision and the robustness against statistical noise. Furthermore, we found that the bias of the estimates of the parameters such as the chemical exchange rate can be reduced by using a spin-lock pulse.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] A theoretical and numerical consideration of the longitudinal and transverse relaxations in the rotating frame2013

    • Author(s)
      Murase K
    • Journal Title

      Magn Reson Imaging

      Volume: 31 Issue: 9 Pages: 1544-1558

    • DOI

      10.1016/j.mri.2013.07.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 温度感受性リポソームを用いたCEST MRI用プローブによる化学シフトの制御に関する検討2014

    • Author(s)
      丸山修紀, 木村敦臣, 上田淳平, 齋藤茂芳, 村瀬研也
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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