| Project/Area Number |
25670535
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGINO Chiaki 神戸大学, 工学(系)研究科(研究院), 准教授 (00313693)
SATO Kazuyoshi 群馬大学, その他(部局等), 助教 (40437299)
NUMAKO Chiya 千葉大学, 理学(系)研究科(研究院), 准教授 (80284280)
NAKAYAMA Masao 神戸大学, 医学(系)研究科(研究院), 研究員 (60582004)
AKASAKA Hiroaki 神戸大学, 医学部附属病院, 助教 (20707161)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 放射線増感 / ナノ粒子 / 放射線療法 / 活性酸素腫 / 膵臓がん / ROS |
|---|
| Outline of Final Research Achievements |
The tumor growth inhibitory effects ofPAA-TiOx nanoparticles combined with X-ray irradiation was observed in vitro and in vivo experiments.The effect was induced by ROS generation followed by DNA damages in cancer cells. Evaluations of long-term toxicity and of molecular mechanisms need to be performed in the nearest future. This strategy might be a novel radiosensitization method using metal nanoparticles
|
