| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Recently, post-transcriptional control of gene expression, mediated by such as microRNA and/or RNA-binding protein, has been considered to play an important role in gene regulation. In this study, we developed a novel method to discover a set of genes of post-transcriptionally regulation using retrovirus vector system. In order to find out genes with post-transcriptionally regulation affected by radiation, we applied this method to pleuripotent stem cell as well as hematopoietic stem cell with or without irradiation and could detect sets of genes of interest. We will perform further investigation to find out genes for therapeutic targets and to clarify the underlying mechanism of translational control.
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