| Project/Area Number |
25670546
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
UMEDA Izumi, O. 独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40160791)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Sadaaki 独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (10585029)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内用療法 / リポソーム / 放射性核種 / 錯体化学 / がん / In-111 / Y-90 / ナノキャリア / がん治療 / がん選択性 / イットリウム90 / 核医学 |
|---|
| Outline of Final Research Achievements |
Application of radionuclide-carrying liposomes to radionuclide therapy for cancer is promising as liposomes are able to deliver large amount of radionuclides to the tumor. However, radionuclides also accumulate in normal tissues such as the liver non-specifically, and cause abdominal radiation exposure. In this study, we devised a strategy whereby radionuclides with the property of metal ions and various chelating ligands to them were encapsulated in liposomes to promote the radionuclide clearance from the normal tissues.
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