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Identification of novel inducing factors pancreatic beta cells by iPS modified technology

Research Project

Project/Area Number 25670556
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

ISHII Hideshi  大阪大学, 医学(系)研究科(研究院), 特任教授(常勤) (10280736)

Co-Investigator(Kenkyū-buntansha) KONNO Masamitsu  大阪大学, 大学院医学系研究科, 寄附講座助教 (80618207)
Co-Investigator(Renkei-kenkyūsha) MORI Masaki  大阪大学, 大学院医学系研究科, 教授 (70190999)
MIMORI Koshi  九州大学, 大学病院, 教授 (50322748)
NAGANO Hiroaki  山口大学, 大学院医学系研究科, 教授 (10294050)
EGUCHI Hidetoshi  大阪大学, 大学院医学系研究科, 准教授 (90542118)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords再生医療 / 再生医学 / 細胞・組織 / 発生・分化 / トランスレーショナルリサーチ
Outline of Final Research Achievements

To identity critical factors for induction of pancreatic beta cells, we developed novel technology of induced pluripotent stem (iPS) interfering method. The study of gene expression allowed the identification of several factors, which play roles in induction and maintenance of pancreatic beta cells. The present study would open an avenue to new efficient approach for human diabetes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (7 results)

  • [Journal Article] Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen.2014

    • Author(s)
      Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T.
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 3591-3591

    • DOI

      10.1038/ncomms4591

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.2014

    • Author(s)
      Lovat, F., Ishii, H., Schiappacassi, M., Fassan, M., Barbareschi, M., Galligioni, E., Gasparini, P., Baldassarre, G., Croce, CM., Vecchione, A.
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 970-977

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma.2014

    • Author(s)
      Fukusumi T, Ishii H, Konno M, Yasui T, Nakahara S, Takenaka Y, Yamamoto Y, Nishikawa S, Kano Y, Ogawa H, Hasegawa S, Hamabe A, Haraguchi N, Doki Y, Mori M, Inohara H.
    • Journal Title

      Br J Cancer

      Volume: 111(3) Issue: 3 Pages: 506-514

    • DOI

      10.1038/bjc.2014.289

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.2014

    • Author(s)
      Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.
    • Journal Title

      Br. J. Cancer

      Volume: 111 Issue: 8 Pages: 1572-80

    • DOI

      10.1038/bjc.2014.454

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1alpha in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis2014

    • Author(s)
      Hamabe, A. Yamamoto, H. Konno, M. Uemura, M. Nishimura, J. Hata, T. Takemasa, I. Mizushima, T. Nishida, N. Kawamoto, K. Koseki, J. Doki, Y. Mori, M. Ishii, H.
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 9 Pages: 1100-8

    • DOI

      10.1111/cas.12487

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition2014

    • Author(s)
      Hamabe, A. Konno, M. Tanuma, N. Shima, H. Tsunekuni, K. Kawamoto, K. Nishida, N. Koseki, J. Mimori, K. Gotoh, N. Yamamoto, H. Doki, Y. Mori, M. Ishii, H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Issue: 43 Pages: 15526-31

    • DOI

      10.1073/pnas.1407717111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cancer Stem Cells of the Digestive System.2014

    • Author(s)
      Colvin, S. H., Nishida, N., Koseki, J., Konno, M., Kawamoto, K., Tsunekuni, K., Doki, Y., Mori, M., Ishii, H.
    • Journal Title

      Jpn. J. Clin. Oncol.

      Volume: 44 Issue: 12 Pages: 1141-1149

    • DOI

      10.1093/jjco/hyu146

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers.2013

    • Author(s)
      Suzuki, Y., Haraguchi, N., Takahashi, H., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Ishii, H., Doki, Y., Mori, M., Yamamoto, H.
    • Journal Title

      Int. J. Oncol.

      Volume: 42 Pages: 161-167

    • DOI

      10.3892/ijo.2012.1713

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Depletion of Jarid1b induces cellular senescence in human colorectal cancer.2013

    • Author(s)
      Ohta, K., Haraguchi, N., Kano, Y., Kagawa, Y., Konno, M., Nishikawa, S., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Nishimura, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Fukami, M., Ishii, M., Yamamoto, H., Doki, Y., Mori, M., Ishii, H.
    • Journal Title

      Intern. J. Oncol.

      Volume: 42 Issue: 4 Pages: 1212-1218

    • DOI

      10.3892/ijo.2013.1799

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy.2013

    • Author(s)
      Nishikawa, S., Konno, M., Hamabe, A., Hasegawa, S., Kano, Y., Ohta, K., Fukusumi, T., Sakai, D., Kudo, T., Haraguchi, N., Satoh, T., Takiguchi, S., Mori, M., Doki,Y., Ishii, H.
    • Journal Title

      Int. J. Oncol.

      Volume: 42 Issue: 4 Pages: 1437-1442

    • DOI

      10.3892/ijo.2013.1837

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adipose-derived mesenchymal stem cells and regenerative medicine.2013

    • Author(s)
      Konno, M., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Nishikawa, S., Ohta, K., Kano, Y., Ozaki, M., Noguchi, Y., Sakai, D., Kudoh, T., Kawamoto, K., Eguchi, H., Satoh, T., Tanemura, M., Nagano, H., Doki, Y., Mori, M., Ishii, H.
    • Journal Title

      Dev. Growth Differ.

      Volume: 55 Issue: 3 Pages: 309-318

    • DOI

      10.1111/dgd.12049

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Innovative drug discovery for intractable cancer stem cells2014

    • Author(s)
      石井秀始
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 難治性消化器癌に対する革新的治療法2014

    • Author(s)
      石井秀始、土岐祐一郎、森正樹
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 創薬標的としての癌幹細胞エピゲノム代謝2014

    • Author(s)
      石井秀始
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Innvovative Medicine for Gastrointestinal Cancer Stem Cells2014

    • Author(s)
      石井秀始
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 難治性消化器癌に対する革新的医療技術の創出2013

    • Author(s)
      石井秀始、土岐祐一郎、森正樹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 難治性消化器癌を克服する新しい創薬展開2013

    • Author(s)
      石井 秀始
    • Organizer
      第23回日本サイトメトリー学会学術集会
    • Place of Presentation
      日本医科大学橘桜会館(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌幹細胞研究の現状と展望2013

    • Author(s)
      石井 秀始
    • Organizer
      第23回日本サイトメトリー学会学術集会
    • Place of Presentation
      日本医科大学橘桜会館(東京都)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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