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Immunotherapy for pancreatic cancer using iPS cell-derived dendritic cell and autophagy-inducing oncolytic virus

Research Project

Project/Area Number 25670560
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionWakayama Medical University

Principal Investigator

Yamaue Hiroki  和歌山県立医科大学, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) Nakamori Mikihito  和歌山県立医科大学, 医学部, 准教授 (10322372)
Kawai Manabu  和歌山県立医科大学, 医学部, 講師 (40398459)
Ojima Toshiyasu  和歌山県立医科大学, 医学部, 講師 (60448785)
Hirono Seiko  和歌山県立医科大学, 医学部, 講師 (60468288)
谷 眞至  滋賀医科大学, 医学部, 教授 (60236677)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords膵癌 / 免疫療法 / 樹状細胞 / 癌治療用ウイルス / オートファジー / 遺伝子治療 / iPS細胞 / 癌 / iPS / 腫瘍溶解型ヘルペスウイルス / iPS由来樹状細胞
Outline of Final Research Achievements

We developed recombinant oncolytic herpes simplex viruses that possess certain antitumor functions and are useful for gastric cancer therapy. A third-generation oncolytic herpes simplex virus type 1(T-01) was used as the backbone to insert foreign sequences. Oncolytic herpes simplex viruses expressing suppressor of cytokine signaling 3 (T-SOCS-3) were constructed, evaluated, and proved to be therapeutic potential. T-SOCS-3 may be a new agent against pancreatic cancer in the near future, and a progress has been made in the basic development of next generation onoclytic virotherapy.In addition, we confirmed that iPS cell derived dendritic cell was able to enhance antitumor immunity at the oncolyitic condition of tumor microenvironment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (42 results)

All 2016 2015 2014 2013

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (7 results)

  • [Journal Article] Grade B pancreatic fistulas do not affect survival after pancreatectomy for pancreatic cancer: A multicenter observational study.2016

    • Author(s)
      Kawai M, Yamaue H. et al.
    • Journal Title

      Surgery

      Volume: xxx Issue: 2 Pages: 293-305

    • DOI

      10.1016/j.surg.2016.02.032

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic neck cancer has specific and oncologic characteristics regardingportal vein invasion and lymph node metastasis.2016

    • Author(s)
      Hirono S, Kawai M, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Yamaue H.
    • Journal Title

      Surgery

      Volume: 159 Issue: 2 Pages: 426-40

    • DOI

      10.1016/j.surg.2015.07.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Randomized Controlled Trial of Pancreaticojejunostomy versus Stapler Closure of the Pancreatic Stump During Distal Pancreatectomy to Reduce Pancreatic Fistula2016

    • Author(s)
      Kawai M, Yamaue H. et al.
    • Journal Title

      Annals of Surgery

      Volume: xxx

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized phase II/III clinical trial of elpamotide forpatients with advanced pancreatic cancer: PEGASUS-PC Study.2015

    • Author(s)
      Yamaue H, Tsunoda T, Tani M, Miyazawa M, Yamao K, Mizuno N, Okusaka T, Ueno H,Boku N, Fukutomi A, Ishii H, Ohkawa S, Furukawa M, Maguchi H, Ikeda M, Togashi Y,Nishio K, Ohashi Y.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 7 Pages: 883-890

    • DOI

      10.1111/cas.12674

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Preoperative evaluation of the confluent drainage veins to the gastrocolic trunk of Henle: understanding the surgical vascular anatomy duringpancreaticoduodenectomy.2015

    • Author(s)
      Miyazawa M, Kawai M, Hirono S, Okada K, Shimizu A, Kitahata Y, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 22 Issue: 5 Pages: 386-391

    • DOI

      10.1002/jhbp.205

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A:Validation of a Nomogram for Predicting the Probability of Carcinoma in Patients With Intraductal Papillary Mucinous Neoplasm in 180 Pancreatic Resection Patients at 3 High-Volume Centers.2015

    • Author(s)
      Shimizu Y, Yamaue H, Maguchi H, Yamao K, Hirono S, Osanai M, Hijioka S, Kanemitsu Y, Sano T, Senda Y, Bhatia V, Yanagisawa A
    • Journal Title

      Pancreas

      Volume: 44 Pages: 459-64

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tips and tricks of the surgical technique for borderline resectable pancreatic cancer: mesenteric approach and modified distal pancreatectomy with en-bloc celiac axis resection.2015

    • Author(s)
      Hirono S, Yamaue H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 22

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A replaced right hepatic artery adjacent to pancreatic carcinoma should be divided to obtain R0 resection in pancreaticoduodenectomy.2015

    • Author(s)
      Okada K, Kawai M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Tani M, Yamaue H
    • Journal Title

      Langenbecks Arch Surg

      Volume: 400 Pages: 57-65

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of Risk Factors for Pancreatic Exocrine Insufficiency After Pancreaticoduodenectomy Using a 13C-Labeled Mixed Triglyceride Breath Test.2015

    • Author(s)
      Hirono S, Murakami Y, Tani M, Kawai M, Okada K, Uemura K, Sudo T, Hashimoto Y, Nakagawa N, Kondo N, Yamaue H
    • Journal Title

      World J Surg

      Volume: 39 Pages: 516-25

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preservation of the Left Gastric Artery on the Basis of Anatomical Features in Patients Undergoing Distal Pancreatectomy with Celiac Axis En-bloc Resection (DP-CAR).2014

    • Author(s)
      Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      World J Surg

      Volume: 38 Pages: 2980-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Randomized clinical trial of isolated Roux-en-Y versus conventional reconstruction after pancreaticoduodenectomy.2014

    • Author(s)
      Tani M, Kawai M, Hirono S, Okada K, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      Br J Surg

      Volume: 101 Pages: 1084-91

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative cholangitis during biliary drainage increases the incidence of postoperative severe complications after pancreaticoduodenectomy.2014

    • Author(s)
      Kitahata Y, Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Shimizu A, Yamaue H
    • Journal Title

      Am J Surg

      Volume: 208 Pages: 1-10

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pylorus-Resecting Pancreaticoduodenectomy Offers Long-Term Outcomes Similar to Those of Pylorus-Preserving Pancreaticoduodenectomy: Results of a Prospective Study.2014

    • Author(s)
      Kawai M, Tani M, Hirono S, Okada K, Miyazawa M, Yamaue H
    • Journal Title

      World J Surg

      Volume: 38 Pages: 1476-1483

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer.2014

    • Author(s)
      Yamaue H, Satoi S, Kanbe T, Miyazawa M, Tani M, Kawai M, Hirono S, Okada K, Yanagimoto H, Kwon AH, Mukouyama T, Tsunoda H, Chijiiwa K, Ohuchida J, Kato J, Ueda K, Yamaguchi T, Egawa S, Hayashi K, Shirasaka T
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73 Pages: 97-102

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolated Roux-en-Y anastomosis of the pancreatic stump in a duct-to-mucosa fashion in patients with distal pancreatectomy with en-bloc celiac axis resection.2014

    • Author(s)
      Okada K, Kawai M, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 21 Pages: 193-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: In comparison to bone marrow-derived DCs.2014

    • Author(s)
      Iwamoto H, Ojima T, Hayata K, Katsuda M, Miyazawa M, Iida T, Nakamura M, Nakamori M, Iwahashi M, Yamaue H
    • Journal Title

      Int J Cancer

      Volume: 134 Pages: 332-341

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer2014

    • Author(s)
      Yamaue H, et al
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73(1) Issue: 1 Pages: 97-102

    • DOI

      10.1007/s00280-013-2323-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: in comparison to bone marrow-derived DCs.2014

    • Author(s)
      Iwamoto H
    • Journal Title

      Int J Cancer.

      Volume: 134 Issue: 2 Pages: 332-341

    • DOI

      10.1002/ijc.28367

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer2013

    • Author(s)
      Tsuji T, Nakamori M, et al.
    • Journal Title

      Int J Cancer

      Volume: 132 Issue: 2 Pages: 485

    • DOI

      10.1002/ijc.27681

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancer vaccine therapy using genetically modified induced pluripotent stem cell-derived dendritic cells expressing the TAA gene2013

    • Author(s)
      Iwamoto H
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 40 Pages: 1575-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current state of oncolytic virotherapy in Japan2013

    • Author(s)
      Nakamori M
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 40 Pages: 553-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The characteristics of pancreatic neck cancer.2016

    • Author(s)
      Yamaue H
    • Organizer
      2016 Gastrointestinal Cancers Symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2016-01-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵臓外科の現状と将来展望2015

    • Author(s)
      山上裕機
    • Organizer
      第28回日本内視鏡外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 次世代外科医へ伝える手術の理論と技術2015

    • Author(s)
      山上裕機
    • Organizer
      第77回日本臨床外科学会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 膵癌治療の現状と将来展望2015

    • Author(s)
      山上裕機
    • Organizer
      第46回日本膵臓学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 安全・確実な定型的膵頭十二指腸切除術2015

    • Author(s)
      山上裕機
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] CEA遺伝子導入iPS細胞由来樹状細胞を用いた癌ワクチン療法の可能性2015

    • Author(s)
      尾島敏康,岩本博光,北谷純也,山上裕機
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] The use of an interposed graft during portal vein and/or superior mesenteric vein reconstruction in pancreatic resection for pancreatic cancer.2015

    • Author(s)
      Yamaue H
    • Organizer
      Gastrointestinal Cancers Symposium
    • Place of Presentation
      America
    • Year and Date
      2015-01-15 – 2015-01-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Can We Reduce Complications Following Pancreatoduodenectomy? The Mesenteric Approach and Clinical Trials.2014

    • Author(s)
      Yamaue H
    • Organizer
      45th Anniversary Meeting of the American Pancreatic Association & Japan Pancreas Society
    • Place of Presentation
      America
    • Year and Date
      2014-11-06
    • Related Report
      2014 Research-status Report
  • [Presentation] The impact of preservation of left gastric artery in distal pacreatectomy with celiac axis en-bloc resection(DP-CAR):Proposal of a novel surgical technique to reduce delayed gastric emptying.2014

    • Author(s)
      Yamaue H, Kawai M, Okada K, Tani M, Hirono S, Miyazawa M, Shimizu A, Kitahata Y
    • Organizer
      48th Annual Meeting of Pancreas Club
    • Place of Presentation
      America
    • Year and Date
      2014-05-02 – 2014-05-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Distal pancreatectomy with celiac axis resection (DP-CAR) for borderline resectable pancreas body carcinoma2014

    • Author(s)
      Yamaue H
    • Organizer
      11th World Congress of the International Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Association of preoperative biliary drainage related complications with postoperative complications after pancreaticoduodenectomy2014

    • Author(s)
      Kawai M
    • Organizer
      11th World Congress of the International Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Pancreatectomy including DP-CAR following neoadjuvant treatment for borderline resectable pancreatic cancer2013

    • Author(s)
      Yamaue H
    • Organizer
      The 38th Congress of The Korean Association of Hepato-Biliary-Pancreatic Surgery
    • Place of Presentation
      Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Clinical efficacy of adjuvant surgery following systemic treatments in patients with initially unresectable pancreatic cancer:Results of a project study for pancreatic surgery by the Japanese society of Hepato-Biliary-Pancreatic Surgery2013

    • Author(s)
      Yamaue H
    • Organizer
      47th Annual Meeting of the Pancreas Club
    • Place of Presentation
      America
    • Related Report
      2013 Research-status Report
  • [Presentation] Surgical indication based on malignant predictors for the patients with branch type IPMN2013

    • Author(s)
      Hirono S
    • Organizer
      Joint Meeting of the International Association of Pancreatology & the Korean Pancreatobiliary Association 2013
    • Place of Presentation
      Korea
    • Related Report
      2013 Research-status Report
  • [Book] 消化器疾患 最新の治療2015-20162015

    • Author(s)
      谷 眞至,山上裕機
    • Total Pages
      3
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Book] 分子細胞治療フロンティア20152014

    • Author(s)
      勝田将裕,山上裕機
    • Total Pages
      8
    • Publisher
      外科分子治療研究会
    • Related Report
      2014 Research-status Report
  • [Book] 膵癌治療up-to-date20152014

    • Author(s)
      谷 眞至,山上裕機
    • Total Pages
      8
    • Publisher
      医学図書出版
    • Related Report
      2014 Research-status Report
  • [Book] 膵癌治療up-to-date20152014

    • Author(s)
      廣野誠子,山上裕機
    • Total Pages
      6
    • Publisher
      医学図書出版
    • Related Report
      2014 Research-status Report
  • [Book] 標準外科学 第13版 第4章外科的診断法 A病歴2013

    • Author(s)
      山上裕機
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] 標準外科学 第13版 第4章外科的診断法 Lナビゲーション2013

    • Author(s)
      山上裕機
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] 標準外科学 第13版 第4章外科的診断法 F腹部の診療法 G直腸、肛門の診察法 H鼠径および大体ヘルニアの診察法 I脈関係の診察法2013

    • Author(s)
      山上裕機
    • Total Pages
      7
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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