| Project/Area Number |
25670570
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOZAWA HIROAKI 東京大学, 医学部附属病院, 講師 (80529173)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Hironori 東京大学, 医学部附属病院, 登録研究員 (20376445)
SUNAMI Eiji 東京大学, 医学部附属病院, 登録研究員 (70345205)
WATANABE Toshiaki 東京大学, 医学部附属病院, 教授 (80210920)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | colitic cancer / 炎症性腸疾患 / 発癌 / ｍＴＯＲ / mTOR |
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| Outline of Final Research Achievements |
In mouse models for colitic cancer using azoxymethan (AOM) and dextran sodium sulfate (DSS), tumors developed mainly in the proximal colon. The expression level of 4E-BP1 was higher in tumors than normal mucosa by immunohistochemical study, which was confirmed by western blotting. However, the level of urine 8-OH-dG as a marker of oxidative stress was unchanged by AOM and/or DSS treatment. The association between colitic cancer and Akt-mTOR signaling axis should be elucidated by more extensive experiments.
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