Analysis of the mechanism for liver metastasis and theresistance to anticancer agents of colorectal cancer

• Project/Area Number: 25670573
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Gifu University
• Principal Investigator: OKUMURA NAOKI 岐阜大学, 医学(系)研究科(研究院), 助教 (80422715)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: c-Met / HGF / colorectal cancer / liver metastasis / TGF-β / EMT / Hepatocyte Growth Factor / TGF- β

Outline of Final Research Achievements

There is a difference in the signaling pathway that HGF and TGF express EMT,even though HGF also induce EMT in the same manner as TGF. That is HGF induces EMT through the ERK / Akt pathway. HGF enhance the effect of 5FU by attenuating the thymidine synthase through the cyclin D1 / E2F-related pathway.

Research Products

• [Presentation] HGFによるEMT誘導時の抗がん剤感受性に関する検討 (2015)
  • Author(s): 福田賢也
  • Organizer: 第70回日本消化器外科学会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2015-07-15
• [Presentation] HGFによるEMT誘導時の抗がん剤感受性 (2015)
  • Author(s): 福田賢也
  • Organizer: 第27回肝胆膵外科学会
  • Place of Presentation: ホテル グランパシフィック LE DAIBA
  • Year and Date: 2015-06-11
• [Presentation] 大腸癌肝転移におけるHGFによるEMT発現と抗癌剤の効果 (2014)
  • Author(s): 福田賢也
  • Organizer: 第25回日本消化器癌発生学会
  • Place of Presentation: ホテル日航福岡
  • Year and Date: 2014-11-13 – 2014-11-15
• [Presentation] The effect of chemotherapeutic drug in the progress of EMT (Epitherial-Mesencymal Transition (2014)
  • Author(s): 福田賢也
  • Organizer: 第73回日本癌学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] HGFによるEMT発現機構メカニズム (2014)
  • Author(s): 福田賢也
  • Organizer: 第114回日本外科学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] HGFによるEMT発現時の抗癌剤感受性について (2013)
  • Author(s): 福田賢也
  • Organizer: 第38回消化器外科学会総会
  • Place of Presentation: サンホテルフェニックス(宮崎)
• [Presentation] 大腸癌肝転移過程におけるEMT状態での抗癌剤効果 (2013)
  • Author(s): 福田賢也
  • Organizer: 第24回消化器癌発生学会
  • Place of Presentation: 石川県立音楽堂(石川県)
• [Presentation] Anticancer drug effect on EMT (Epitherial-mesencymal transition) in the progress of colon cancer liver metastases (2013)
  • Author(s): 福田賢也
  • Organizer: 第72回日本癌学会
  • Place of Presentation: パシフィコ横浜(神奈川)
• [Presentation] EMT発現状況における化学療法の影響 (2013)
  • Author(s): 福田賢也
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館(京都)