Find out of Nrf2 function and development of the inhibitor of Nrf2 for cancer stem cells

• Project/Area Number: 25670576
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: KUDO Toshihiro 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (20593859)
• Co-Investigator(Kenkyū-buntansha): ISHII Hideshi 大阪大学, 大学院医学系研究科, 特任教授(常勤) (10280736) ; KONNO Masamitsu 大阪大学, 大学院医学系研究科, 寄附講座助教 (80618207)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 癌 / 発現制御 / 薬学

Outline of Final Research Achievements

Recently it is reported that Nrf2 play an important role for cancer malignancy. So it is thought that the inhibitor of Nrf2 is effective for cancer therapy. In this study we tried to screening for the inhibitor of Nrf2. And we succeeded to get the many kinds of inhibitor of Nrf2.

Research Products

• [Journal Article] Safety and pharmacokinetics of S-1 in a recurrent colon cancer patient with chronic myeloid leukemia treated with dasatinib: A case report. (2014)
  • Author(s): Sueda T., Kudo T., Sakai D., Uemura M., Nishimura J., Hata T., Takemasa I., Mizushima T., Yamamoto H., Ezoe S., Matsumoto K., Doki Y., Mori M., Satoh T.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 74 Issue: 6 Pages: 1321-1324
  • DOI: 10.1007/s00280-014-2620-8
  • Peer Reviewed
• [Journal Article] Depletion of Jarid1b induces cellular senescence in human colorectal cancer. (2013)
  • Author(s): Ohta, K., Haraguchi, N., Kano, Y., Kagawa, Y., Konno, M., Nishikawa, S., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Nishimura, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Fukami, M., Ishii, M., Yamamoto, H., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Intern. J. Oncol. Volume: 42 Issue: 4 Pages: 1212-1218
  • DOI: 10.3892/ijo.2013.1799
  • Peer Reviewed
• [Journal Article] Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. (2013)
  • Author(s): Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H.
  • Journal Title: Mol. Clin. Oncol. Volume: 1 Pages: 753-757
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy. (2013)
  • Author(s): Nishikawa, S., Konno, M., Hamabe, A., Hasegawa, S., Kano, Y., Ohta, K., Fukusumi, T., Sakai, D., Kudo, T., Haraguchi, N., Satoh, T., Takiguchi, S., Mori, M., Doki,Y., Ishii, H.
  • Journal Title: Int. J. Oncol. Volume: 42 Issue: 4 Pages: 1437-1442
  • DOI: 10.3892/ijo.2013.1837
  • Peer Reviewed
• [Journal Article] Adipose-derived mesenchymal stem cells and regenerative medicine. (2013)
  • Author(s): Konno, M., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Nishikawa, S., Ohta, K., Kano, Y., Ozaki, M., Noguchi, Y., Sakai, D., Kudoh, T., Kawamoto, K., Eguchi, H., Satoh, T., Tanemura, M., Nagano, H., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Dev. Growth Differ. Volume: 55 Issue: 3 Pages: 309-318
  • DOI: 10.1111/dgd.12049
  • Peer Reviewed
• [Journal Article] Eradication of therapy-resistant cancer cells in gastrointestinal organs. (2013)
  • Author(s): Nishikawa, S., Konno, M., Hamabe, A., Hasegawa, S., Ogawa, H., Kano, Y., Fukusumi, T., Ohta, K., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Haraguchi, N., Satoh, T., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Mol. Clin. Oncol. Volume: 1 Pages: 15-17
  • Peer Reviewed
• [Presentation] Clinical validation of a novel multiplex kit for all RAS mutations in colorectal cancer: Results of RASKET(RAS Key Testing)prospective multicenter… (2014)
  • Author(s): Kudo T., Hironaka S, Okamoto W, Yoshino T, Muro K, Taniguchi H, Akagi K, Nishina T, Kajiwara T, DendaT.
  • Organizer: ESMO 2014
  • Place of Presentation: IFEMA ‐ Feria de Madrid（スペイン）
  • Year and Date: 2014-09-26 – 2014-09-30
• [Presentation] mFOLFOX6 + ベバシズマブ療法により高アンモニア血症を来すも分岐鎖アミノ酸製剤により継続可能となった進行結腸がんの一例 (2013)
  • Author(s): 工藤敏啓、佐藤 太郎、坂井 大介、杉浦 孝司、竹政 伊知朗、山本 浩文、石井 秀始、森 正樹
  • Organizer: 第１１回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台国際センター(宮城県）