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Development of novel cell therapeutic strategy using unlicenced NK cells combined with molecular target medicine for liver cancer

Research Project

Project/Area Number 25670581
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

OHDAN Hideki  広島大学, 医歯薬保健学研究院(医), 教授 (10363061)

Co-Investigator(Kenkyū-buntansha) TANAKA Yuka  広島大学, 医歯薬保健学研究院(医), 准教授 (90432666)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsNK細胞 / 分子標的薬
Outline of Final Research Achievements

NK cells have a potential role in immune surveillance of HCC. Self-recognition of HLA through killer immunoglobulin-like receptors (KIR) confers competence to NK cells-a process termed "licensing." We investigated the effect of NK-cell licensing on the susceptibility of patients to HCC recurrence. A total of 170 patients with HCC who underwent curative hepatectomy were enrolled. We analyzed their KIR-HLA genotypes. The presence of KIR2DL1-C2, KIR2DL2-C1, KIR3DL1-BW4, or KIR3DL2-A3/11, functional compound genotypes that intrinsically license NK cells, did not markedly affect HCC recurrence. However, the multiplicity of those compound KIR-HLA genotypes was significantly associated with the HCC recurrence rate, i.e., the cumulative risk of recurrence in patients with at least three compound genotypes was significantly lower than that in patients with one or two compound genotypes. Patients at high risk of HCC recurrence after curative hepatectomy could be identified by KIR-HLA genotyping.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Impact of multiplicity of functional KIR-HLA compound genotypes on hepatocellular carcinoma2015

    • Author(s)
      Tanimine N, Ohdan H
    • Journal Title

      Oncoimmunology

      Volume: 4(1)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy2014

    • Author(s)
      Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K, Ohdan H.
    • Journal Title

      Cancer Immunol Res

      Volume: 2(12) Issue: 12 Pages: 1142-1147

    • DOI

      10.1158/2326-6066.cir-14-0091

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fasting Enhances TRAIL-Mediated Liver Natural Killer Cell Activity via HSP70 Upregulation.2014

    • Author(s)
      Dang VT, Tanabe K, Tanaka Y, Tokumoto N, Misumi T, Saeki Y, Fujikuni N, Ohdan H.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 10 Pages: e110748-e110748

    • DOI

      10.1371/journal.pone.0110748

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] KIR-HLA遺伝子型の肝細胞癌切除後再発予後に対する影響2014

    • Author(s)
      谷峰直樹, 田中友加, 小林剛, 石山宏平, 井手健太郎, 大平真裕, 田原裕之, 田代裕尊, 大段秀樹.
    • Organizer
      第23回日本組織適合性学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-13 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Impact of natural killer cell licensing associated with KIR-HLA genotype on the recurrence of hepatocellular carcinoma after curative hepatectomy: Can the KIR-HLA genotype be a selection criterion for potential donors for liver transplantation with adoptive immunotherapy using NK cells extracted from liver allografts?2014

    • Author(s)
      Tanimine N, Tanaka Y, Ohdan H.
    • Organizer
      WTC 2014
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-07-26 – 2014-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] NK 細胞License 機構の肝細胞癌切除後再発予後に対する影響2014

    • Author(s)
      谷峰直樹, 田中友加, 小林剛, 石山宏平, 井手健太郎, 大平真裕, 田原裕之, 田代裕尊, 大段秀樹.
    • Organizer
      第32回日本肝移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Risk factors of the hepatocellular carcinoma recurrence after living donor liver transplantation; a single center experience retrospective analysis2014

    • Author(s)
      Tanimine N, Tanaka Y, Ishiyama K, Kobayashi T, Ide K, Ohira M, Tahara H, Tashiro H, Hideki Ohdan H.
    • Organizer
      ILTS 2014
    • Place of Presentation
      London, United Kingdom
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Adjuvant immunotherapy using liver NKCells enhances protective immunity against HCC recurrence and infectious complications in live rtransplantation.2014

    • Author(s)
      大段秀樹
    • Organizer
      第114回日本外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肝移植後肝細胞癌再発に対する腫瘍外因子の影響2013

    • Author(s)
      谷峰直樹、田中友加, 安部智之, 朴金連, 石山宏平, 井手健太郎, 大平真裕, 田代裕尊, 大段秀樹.
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 肝癌治療としての肝移植の近未来2013

    • Author(s)
      大段秀樹
    • Organizer
      第40回日本臓器保存生物医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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