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The role of macrophage of spleen in wound healing and cancer progression

Research Project

Project/Area Number 25670583
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

Shirabe Ken  九州大学, 医学(系)研究科(研究院), 共同研究員 (70264025)

Co-Investigator(Kenkyū-buntansha) SOEJIMA Yuji  九州大学, 医学研究院, 共同研究員 (30325526)
IKEDA Tetsuo  九州大学, 大学病院, 准教授 (60585701)
YOSHIZUMI Tmoharu  九州大学, 医学研究院, 准教授 (80363373)
IKEGAMI Toru  九州大学, 大学病院, 助教 (80432938)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脾臓 / 創傷治癒 / 肝癌 / 免疫 / 肝臓外科学
Outline of Final Research Achievements

In terms of wound healing study, skin defect mice model was established. And Ly6C macrophage, which was reported to be related to wound healing, was harvested from spleen. Although splenectomy in skin defect mice modelwas performed, there was no significant difference in wound healing between mice with and without splenectomy.
In terms of cancer progression, our clinical data showed that splenomegaly was significant poor prognostic factor after hepatectomy for hepatocellular carcinoma(HCC). The prognosis after hepatectomy for HCC and simultaneous splenectomy for splenomegaly was same as that in those who underwent hepatectomy for HCC and without splenomegaly. Splenectomy may improve long term prognosis after hepatectomy. We showed that the number of immunosuppressive cells increased in the spleen in the patients with liver cirrhosis (LC). Therefore, in the patients with LC, the cause of immunosuppressive state may be spleen.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 肝細胞癌肝切除に対する脾容積の意義と脾摘術の効果2015

    • Author(s)
      木村光一、武石一樹、川中博文、坂田一仁、下川雅弘、吉田佳弘、今井大祐、別城悠樹、伊藤心二、播本憲史、池上 徹、吉住朋晴、調  憲、前原喜彦
    • Organizer
      第22回日本門脈圧亢進症学会総会
    • Place of Presentation
      パシフィコ横浜アネックスホール
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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