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The improvement of drug delivery based on the normalization of cancer stroma and its application for the treatment of pancreatic cancer

Research Project

Project/Area Number 25670584
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

OHUCHIDA Kenoki  九州大学, 先端医療イノベーションセンター, 講師 (20452708)

Co-Investigator(Kenkyū-buntansha) MAEYAMA Ryo  九州大学, 大学病院, 助教研究者 (10611668)
MORIYAMA Taiki  九州大学, 医学研究院, 共同研究員研究者 (70586859)
Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords膵がん / 膵星細胞 / 細胞外基質 / 膵癌 / 癌間質相互作用 / 癌浸潤
Research Abstract

In the present study, we focused on tumor-related stroma and its remodeling and normalization and mainly investigated the mechanism of cancer-stromal interaction between cancer cells and pancreatic stellate cells. Then, we identified the several molecules, which are related with the extracellular matrices derived from pancreatic stellate cells and found that such matrices affect the invasion and migration of pancreatic cancer cells. These data suggest that the remodeling of cancer stroma by normalization based on the novel molecules may lead to the development of new therapy for pancreatic cancer.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (23 results)

All 2014 2013 Other

All Journal Article (14 results) Presentation (9 results)

  • [Journal Article] Expression of Glucagon.Like Peptide 1 Receptor and Its Effects on Biological Behavior in Pancreatic Neuroendocrine Tumors2014

    • Author(s)
      Ana Ines Cases, Takao Ohtsuka, Minoru Fujino, Noboru Ideno, Shingo Kozono, Ming Zhao, Kenoki Ohuchida, Shinichi Aishima, Masatoshi Nomura, Yoshinao Oda, Kazuhiro Mizumoto, Masao Tanaka
    • Journal Title

      Pancreas

      Volume: 43(1) Pages: 1-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Tissue Tablet Method : An Efficient Tissue Banking Procedure Applicable to Both Molecular Analysis and Frozen Tissue Microarray2014

    • Author(s)
      Nobuhiro Torata, Kenoki Ohuchida, Shin Akagawa, Lin Cui, Shingo Kozono, Kazuhiro Mizumoto, Shinichi Aishima, Yoshinao Oda, Masao Tanaka
    • Journal Title

      Human Pathology

      Volume: 45(1) Pages: 143-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] 特集タイトル : 臨床検体から導き出す消化器病研究テーマ2014

    • Author(s)
      大内田研宙、大塚隆生、水元一博、田中雅夫
    • Journal Title

      6)膵液中バイオマーカーで膵疾患の診断、早期発見はできるか分子消化器病

      Volume: vol.11 no.1

    • Related Report
      2013 Final Research Report
  • [Journal Article] Kindlin-1 expression is involved in migration and invasion in pancreatic cancer2013

    • Author(s)
      Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto and Masao Tanaka
    • Journal Title

      International Journal of Oncology

      Volume: 42 Pages: 1360-1366

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pancreatic stellate cells in hypoxia enhance pancreatic cancer invasiveness via secretion of connective tissue growth factor2013

    • Author(s)
      Daiki Eguchi , Naoki Ikenaga , Kenoki Ohuchida, Shingo Kozono , Lin Cui, Fujiwara Kenji , Koji Shindo, Takao Ohtsuka, Shunichi Takahata, Kazuhiro Mizumoto and Masao Tanaka
    • Journal Title

      Journal of Surgical Research

      Volume: 181 Pages: 225-33

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells2013

    • Author(s)
      Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Naoki Ikenaga, Kenji Fujiwara, Ming Zhao, Lin Cui, Koji Shindo, Kazuhiro Mizumoto, and Masao Tanaka
    • Journal Title

      Cancer Research

      Volume: 73 Pages: 2345-56

    • Related Report
      2013 Final Research Report
  • [Journal Article] Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma2013

    • Author(s)
      Prawej Mahawithitwong, Kenoki Ohuchida, Naoki Ikenaga, Hayato Fujita, Ming Zhao, Shingo Kozono, Koji Shindo, Takao Ohtsuka, Shinichi Aishima, Kazuhiro Mizumoto, Masao Tanaka
    • Journal Title

      Pancreas

      Volume: 42 Pages: 663-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Biological evaluation of protein nanocapsules containing doxorubicin2013

    • Author(s)
      Riki Toita, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong-Hun Kang, Kenoki Ohuchida, Makoto Hashizume
    • Journal Title

      International Journal of Nanomedicine

      Volume: 8 Pages: 1989-1999

    • Related Report
      2013 Final Research Report
  • [Journal Article] Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells2013

    • Author(s)
      Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, and Masao Tanaka
    • Journal Title

      Pancreas

      Volume: 42(8) Pages: 1283-90

    • Related Report
      2013 Final Research Report
  • [Journal Article] S100A4 mRNA expression level is a predictor of radiosensitivity of pancreatic cancer cells2013

    • Author(s)
      Shingo Kozono, Kenoki Ohuchida, Takao Ohtsuka, Lin Cui , Daiki Eguchi , Kenji Fujiwara , Ming Zhao , Kazuhiro Mizumoto, Masao Tanaka
    • Journal Title

      Oncology Reports

      Volume: 30(4) Pages: 1601-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] MAL2 expression predicts distant metastasis and short survival in pancreatic cancer2013

    • Author(s)
      Daiki Eguchi, Kenoki Ohuchida, Shingo Kozono, Naoki Ikenaga, Koji Shindo, Lin Cui, Kenji Fujiwara, Shin Akagawa, Takao Ohtsuka, Shunichi Takahata, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka
    • Journal Title

      Surgery

      Volume: 154(3) Pages: 573-82

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fibroblasts expressing podoplanin enhance the tumor progression of invasive ductal carcinoma of pancreas2013

    • Author(s)
      Shindo Koji, Aishima Shinichi, Ohuchida Kenoki, Fujiwara Kenji, Mizumoto Kazuhiro, Tanaka Masao, Oda Yoshinao
    • Journal Title

      Molecular Cancer

      Volume: 12(1) Pages: 168-168

    • Related Report
      2013 Final Research Report
  • [Journal Article] 腫瘍内 heterogeneityに着目した膵癌個別化治療の可能性2013

    • Author(s)
      大内田研宙大塚隆生水元一博田中雅夫
    • Journal Title

      腫瘍個別化から細胞個別化へ.胆と膵

      Volume: Vol.30(2) Pages: 165-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mass Spectrometry-based Metabolic Profiling of Gemcitabine-sensitive and Gemcitabine-resistant Pancreatic Cancer Cells

    • Author(s)
      Yoshinori Fujimura, Naoki Ikenaga, Kenoki Ohuchida, Daiki Setoyama, Miho Irie, Daisuke Miura, Hiroyuki Wariishi, Masaharu Murata, Kazuhiro Mizumoto, Makoto Hashizume and Masao Tanaka
    • Journal Title

      Pancreas

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] CD166 Expression Characterized Tumorigenicity, and Invasive and Migratory Activities of Pancreatic Cancer Cell Lines2013

    • Author(s)
      Fujiwara K, Ohuchida K, Akagawa S, Ohtsuka T, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of Glucagon-like Peptide 1 Recepter and Biological Behavior in Pancreatic Neuroendocrine Tumors2013

    • Author(s)
      Cases A.I., Ohtsuka T, Fujino M, Ideno N, Kzono S, Zhao M, Ikenaga N, Ohuchida K, Oda Y, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical significance of GNAS mutation for invasive pancreatic carcinoma distinct from/derived from intraductal papillary mucinous neoplasm(IPMN) of the pancreas2013

    • Author(s)
      Ideno N, Ohtsuka T, Tamura K, Aso T, Ohuchida K, Takahata S, Oda Y, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Salinomycin induced Autophagy and is Related with its Killing Effect for Pancreatic Cells2013

    • Author(s)
      Nakata K, Zhao M, Ohuchida K, Miyasaka Y, Maeyama R, Ohtsuka T, Nagai E, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Treatment Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreatic Based on the Assessment of Recurrence in the Remnant Pancreas after Resection : A Retrospective Review2013

    • Author(s)
      Tamura K, Ohtsuka T, Ideno N, Aso T, Shindo K, Oda Y, Ohuchida K, Takahata S, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami, 2013
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Reduced Anterior Gradient 2 Expression is Induced by EMT and Correlated with Poor Outcome in Pancreatic Ductal Adenocarcinoma2013

    • Author(s)
      Mizuuchi Y, Aishima S, Ohuchida K, Shindo S, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Histon Deacetylase 1 is Responsible for Radioresistance of Pancreatic Cancer cells2013

    • Author(s)
      Tanaka T, Ohuchida K, Mizumoto K, Kozono S, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparisons of Characteristics of Peritoneal Fibroblasts in Dissemination with those of Mesothelial Cells and Pancreatic Stellate Cells in Pancreatic Cancer2013

    • Author(s)
      Akagawa S, Ohuchida K, Torada N, Eguchi D, Kozono S, Ohtsuka T, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical Significance of Stromal CD90 and alpha-SMA Expression in Pancreatic Cancer2013

    • Author(s)
      Sada M, Ohuchida K, Fujiwara K, Horioka K, Tanaka T, Zheng B, Cases A.I., Akagawa S, Shindo K, Ohtsuka T, Takahata S, Oda Y, Mizumoto K, Tanaka M
    • Organizer
      44th Annual Meeting, Miami
    • Place of Presentation
      Ammerican Pancreatic Association
    • Related Report
      2013 Final Research Report

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Published: 2014-07-25   Modified: 2016-11-25  

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