Biological and clinical significance of niche during carcinogenesis in pancreatic cancer

• Project/Area Number: 25670585
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418)
• Co-Investigator(Kenkyū-buntansha): SHIMAMOTO Masaya 九州大学, 大学病院, 助教 (00457433) ; SHIMIZU Yukiko 九州大学, 大学病院, 助教 (10404021) ; SAKAI Hiroshi 九州大学, 医学研究院, 共同研究員 (80611665) ; OHUCHIDA Kenoki 九州大学, 大学病院, 助教 (20452708)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 膵癌 / ニッチ / 膵星細胞 / carcinogenesis / 発癌 / 間質ニッチ / TGFβ / 癌間質相互作用

Outline of Final Research Achievements

We have identified desmoplastic reaction around early PanIN lesion of the genetically engineered mouse model of pancreatic cancer which resembles human pancreatic cancer in pathological characteristic, as well as in disease progression. Pancreatic stellate cells, which are implicated in desmoplastic reaction, have been investigated because of the strong ability to increase malignant potential of cancer cells. Our data suggested that subpopulation of stellate cells had the role in carcinogenesis of pancreatic cancer, which were profiled by CD90, one of the mesenchymal stem cell markers, and CD146 which is known as adhesion molecule.

Research Products

• [Journal Article] Pancreatic Cancer: Clinical Significance of Biomarkers (2014)
  • Author(s): Mori M, Chiba T, Nakamizo A, Kumashiro R, Murata M, Akahoshi T, Tomikawa M, Ohuchida K, Ohtsuka T,Mizumoto K, Hashizume M,Tanaka M
  • Journal Title: Gastro Intestinal Tumors Volume: 1 Issue: 1 Pages: 33-40
  • DOI: 10.1159/000354996
  • Peer Reviewed
• [Journal Article] Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer. (2014)
  • Author(s): Akagawa S, Ohuchida K, Torata N, Hattori M, Eguchi D, Fujiwara K, Kozono S, Cui L, Ikenaga N, Ohtsuka T, Oishima S, Mizumoto K, Oda Y, Tanaka M
  • Journal Title: Int J Oncol Volume: 45 Issue: 1 Pages: 113-120
  • DOI: 10.3892/ijo.2014.2391
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Micro RNA-373 is Down-regulated in Pancreatic Cancer and Inhibits Cancer Cell Invasion (2014)
  • Author(s): Nakata K, Ohuchida K, Mizumoto K, Aishima S, Oda Y, Nagai E, Tanaka M
  • Journal Title: Ann Surg Oncol Volume: 21 Issue: S4 Pages: 564-574
  • DOI: 10.1245/s10434-014-3676-8
  • Peer Reviewed
• [Journal Article] CD166/ALCAM expression is characteristic of tumorigenicity and invasive and migratory activities of pancreatic cancer cells. (2014)
  • Author(s): Fujiwara K, Ohuchida K, Sada M, Horioka K, Ulrich CD 3rd, Shindo K, Ohtsuka T, Takahata S, Mizumoto K, Oda Y, Tanaka M.
  • Journal Title: PLoS One Volume: 9 Issue: 9 Pages: 1-11
  • DOI: 10.1371/journal.pone.0107247
  • Peer Reviewed / Open Access
• [Journal Article] Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells. (2013)
  • Author(s): Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Naoki Ikenaga, Kenji Fujiwara, Ming Zhao, Lin Cui, Koji Shindo, Kazuhiro Mizumoto, and Masao Tanaka
  • Journal Title: Cancer Research Volume: 73 Issue: 7 Pages: 2345-2356
  • DOI: 10.1158/0008-5472.can-12-3180
  • Peer Reviewed
• [Presentation] 膵癌関連繊維芽細胞におけるCD146発現と膵がんの進展抑制 (2014)
  • Author(s): 鄭彪、大内田研宙、崔林、水内祐介、藤原謙次、赤川進、堀岡宏平、田中友晴、佐田政史、仲田興平、前山良、大塚隆生、小田義直、水元一博、田中雅夫
  • Organizer: 第45回日本膵臓学会大会
  • Place of Presentation: 北九州市
  • Year and Date: 2014-07-11
• [Presentation] 膵癌細胞からの作用により膵星細胞中のNPAS1が増加する (2014)
  • Author(s): 藤原謙次、大内田研宙、赤川進、大塚隆夫、高畑俊一、水元一博、田中雅夫
  • Organizer: 第45回日本膵臓学会大会
  • Place of Presentation: 北九州市
  • Year and Date: 2014-07-11
• [Presentation] Tranilastによる膵星細胞についての検討
  • Author(s): 田中友晴
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
• [Book] Annual Review 2014 消化器 (2014)
  • Author(s): 佐田政史、水元一博、大内田研宙、大塚隆生、田中雅夫
  • Total Pages: 306
  • Publisher: 中外医学社