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Development of novel therapies that focus on autophagy-induced cancer cell substrate clearance function

Research Project

Project/Area Number 25670587
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

NAGAI Eishi  九州大学, 医学(系)研究科(研究院), 准教授 (30264021)

Co-Investigator(Kenkyū-buntansha) NAKATA Kohei  九州大学, 医学研究院, 共同研究員 (30419569)
MIYASAKA Yoshihiro  九州大学, 医学研究院, 助教 (40507795)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌関連線維芽細胞 / 細胞外基質クリアランス / 上皮間葉移行 / オートファジー
Outline of Final Research Achievements

During invasion process of pancreatic cancer, we focused on extracellular matrix clearance by cancer-associated fibroblasts and the epithelial-mesenchymal transition of cancer cells, and we thought pancreatic cancer cells were also involved in matrix remodeling. So we studied the relationship between extracellular matrix clearance and autophagy in pancreatic cancer cells. Autophagy is a metabolic mechanism degrades self components,
Autophagy of pancreatic cancer cells in human sample is enhanced, so it could be a therapeutic target. Invasion ability of pancreatic cancer cells was suppressed by autophagy inhibitor 3-MA, and proliferation of pancreatic cancer cells was also inhibited by the knock down of autophagy-related gene Atg7 using shRNA. Furthermore we reported that the downregulation of protein of AGR2 in pancreatic cancer is a useful prognostic marker induced by epithelial-mesenchymal transition.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Micro RNA-373 is Down-regulated in Pancreatic Cancer and Inhibits Cancer Cell Invasion2014

    • Author(s)
      Nakata K, Ohuchida K, Mizumoto K, Aishima S, Oda Y, Nagai E, Tanaka M
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Issue: S4 Pages: 564-574

    • DOI

      10.1245/s10434-014-3676-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 膵癌の肝転移におけるfollistatin-like1の役割2014

    • Author(s)
      堀岡宏平、大内田研宙、江口大樹、佐田政史、田中友晴、赤川進、藤原謙次、鄭彪、仲田興平、宮坂義浩、前山良、大塚隆生、水元一博、田中雅夫
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-04-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Salinomycin induced Autophagy and is Related with its Killing Effect for Pancreatic Cells

    • Author(s)
      Nakata K
    • Organizer
      Ammerican Pancreatic Association, 44th Annual Meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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