| Project/Area Number |
25670594
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka University |
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Principal Investigator |
MIYAGAWA Shigeru 大阪大学, 医学(系)研究科(研究院), 特任准教授(常勤) (70544237)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Koichi 大阪大学, 大学院医学系研究科, 准教授 (40379235)
YOSHIOKA Daisuke 大阪大学, 医学部附属病院, 助教 (40645959)
SAITO Tetsuya 大阪大学, 大学院医学系研究科, 特任助教 (10644891)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | iPS細胞 / 心不全 / 心筋細胞 / 三次元組織化 / 心筋分化 / 機械的刺激 |
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| Outline of Final Research Achievements |
The established differentiation of cardiomyocytes derived from iPS cells are expected to result in better efficacy of cell transplantation therapy. The differentiating cardiomyocytes were transplanted onto adult nude rate hearts. In the transplanted iPS cardiomyocytes in vivo, cardiac specific marker was much more expressed than the cardiomyocytes cultured in vitro. This result suggests that the environment that imitates the condition of cardiomyocytes differentiation promote the differentiation of iPS-CMs. The mechanical stretch modulated cell alignment and maturation gene expression in vitro.
The differentiation of cardiomyocytes derived IPS cells might be promoted in vitro by mechanical stretching.
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