| Project/Area Number |
25670597
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Ryo 佐賀大学, 医学部, 助教 (70530187)
MORITA Shigeki 佐賀大学, 医学部, 教授 (70243938)
ITOH Manabu 佐賀大学, 医学部, 助教 (50555084)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓血管外科 / 再生医療 / 組織工学 / 幹細胞 / 自己細胞 / ３次元化組織 / 心臓血管外科学 / 弁膜症 |
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| Outline of Final Research Achievements |
The purpose of our present study is to develop a novel strategy to fabricate scaffold-free vascular tissue utilizing the spheroid formation and self-assembling of spheroid.The commercially available human umbilical vein endothelial cell, human aorta smooth muscle cell, and human normal dermal fibroblasts were purchased. Thase cells were formed vascular type tissue spheroids. We also develop the simple bio-fabrication system.In this system, vascular type patch were proscessed to form vascular patch like construct and vascular-shape construct.Our strategy is very simple, but several distinct characteristics compaired to reported trategy.Without expensive devices, complicated procedure, we can fabricate scaffold-free three-dimensional vascular structure. Our novel 3-D vascular fabrication system can conveniently generate completely scaffold-free vascular structures. The strategies can support vascular tissue engineering and regenerative therapy.
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