| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In this study, a biovalve for total artificial heart was developed using the "in-body tissue architecture" technology. A specially designed acrylic mold was placed in dorsal subcutaneous pouches of goats for 1-2 months. After extraction, the cylindrical mold was removed to obtain the biovalve. We fabricated three different forms of biovalves and evaluated their function in vitro using a mock circulation circuit to determine the optimal biovalve form for total artificial heart. The developed biovalves demonstrated good function in in vitro study. Based on the evaluation results of three kinds of biovalves, the biovalve for total artificial heart was developed.
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