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Application of in-body tissue-engineered heart valve (biovalve) to total artificial heart

Research Project

Project/Area Number 25670603
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Sumikura Hirohito  国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsバイオバルブ / 全人工心臓 / 人工弁 / 自己組織 / 模擬循環回路
Outline of Final Research Achievements

In this study, a biovalve for total artificial heart was developed using the "in-body tissue architecture" technology. A specially designed acrylic mold was placed in dorsal subcutaneous pouches of goats for 1-2 months. After extraction, the cylindrical mold was removed to obtain the biovalve. We fabricated three different forms of biovalves and evaluated their function in vitro using a mock circulation circuit to determine the optimal biovalve form for total artificial heart. The developed biovalves demonstrated good function in in vitro study. Based on the evaluation results of three kinds of biovalves, the biovalve for total artificial heart was developed.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (51 results)

All 2017 2016 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (43 results) (of which Int'l Joint Research: 15 results)

  • [Journal Article] Development of a stent-biovalve with round-shaped leaflets: in vitro hydrodynamic evaluation for transcatheter pulmonary valve implantation (TPVI).2016

    • Author(s)
      Sumikura H, Nakayama Y, Ohnuma K, Takewa Y, Tatsumi E.
    • Journal Title

      J Artif Organs

      Volume: 19(4) Issue: 4 Pages: 357-363

    • DOI

      10.1007/s10047-016-0909-6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sutureless aortic valve replacement using a novel autologous tissue heart valve with stent (stent biovalve): proof of concept2015

    • Author(s)
      Kishimoto S, Takewa Y, Nakayama Y, Date K, Sumikura H, Moriwaki T, Nishimura M, Tatsumi E
    • Journal Title

      J Artif Organs

      Volume: 18(2) Issue: 2 Pages: 185-190

    • DOI

      10.1007/s10047-015-0817-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of self-expanding valved stents with autologous tubular leaflet tissues for transcatheter valve implantation.2015

    • Author(s)
      Funayama M, Sumikura H, Takewa Y, Tatsumi E, Nakayama Y.
    • Journal Title

      J Artif Organs

      Volume: 未定 Issue: 3 Pages: 228-235

    • DOI

      10.1007/s10047-015-0820-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro hydrodynamic evaluation of a biovalve with stent (tubular leaflet type) for transcatheter pulmonary valve implantation2015

    • Author(s)
      Sumikura H, Nakayama Y, Ohnuma K, Kishimoto S, Takewa Y, Tatsumi E
    • Journal Title

      J Artif Organs

      Volume: 18(4) Issue: 4 Pages: 307-314

    • DOI

      10.1007/s10047-015-0851-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014

    • Author(s)
      Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: (in press) Issue: 1 Pages: 1-10

    • DOI

      10.1002/jbm.b.33186

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro evaluation of a novel autologous aortic valve (Biovalve) with a pulsatile circulation circuit2014

    • Author(s)
      Sumikura H, Nakayama Y, Ohmuma K, Takewa Y, Tastumi E
    • Journal Title

      Artif Organs

      Volume: (in press) Issue: 4 Pages: 282-9

    • DOI

      10.1111/aor.12173

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method2014

    • Author(s)
      Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Moriwaki T, Yamanami M, Oie T, Tatsumi E, Uechi M, Nakayama Y
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: Dec 9 Issue: 5 Pages: 1-10

    • DOI

      10.1002/jbm.b.33086

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fundamental Examination of an Application of Wearable Pneumatic Drive Unit for Pneumatic Total Artificial Heart System2014

    • Author(s)
      住倉博仁, 本間章彦, 大沼健太郎, 妙中義之, 武輪能明, 梅木昭秀, 水野敏秀, 築谷朋典, 片桐伸将, 藤井 豊、角田幸秀、向林 宏、片野一夫、福井康裕、巽 英介
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 134 Issue: 6 Pages: 839-847

    • DOI

      10.1541/ieejeiss.134.839

    • NAID

      130004870061

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 生体内組織形成術で作製した心臓弁の長期移植評価と生きたグラフトとしての可能性の検討2017

    • Author(s)
      武輪能明、中山泰秀、住倉博仁、飯塚 慶、秋山大地、片桐伸将、竹下大輔、巽 英介
    • Organizer
      日本再生医療学会総会 (16)
    • Place of Presentation
      仙台市
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自家組織からなる心臓弁の長期移植評価と組織学的検討2017

    • Author(s)
      武輪能明、中山泰秀、住倉博仁、飯塚 慶、秋山大地、片桐伸将、竹下大輔、妙中義之
    • Organizer
      日本再生医療学会総会 (16)
    • Place of Presentation
      仙台市
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Long-term evaluation of a novel autologous tissue heart valve2017

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Iizuka K, Akiyama D, Tatsumi E
    • Organizer
      The Heart Valve Society 2017 Scientific Meeting
    • Place of Presentation
      Monte Carlo
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成長に対応可能な心臓血管外科手術用グラフトの開発2017

    • Author(s)
      武輪能明、中山泰秀、住倉博仁、飯塚 慶、秋山大地、妙中義之、巽 英介
    • Organizer
      日本心臓血管外科学会学術集会 (47)
    • Place of Presentation
      港区
    • Year and Date
      2017-02-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] バイオバルブ心臓弁の長期移植評価と生きたグラフトとしての可能性の検討2016

    • Author(s)
      武輪能明、中山泰秀、住倉博仁、飯塚 慶、秋山大地、片桐伸将、竹下大輔、小崎智史、妙中義之、巽 英介
    • Organizer
      日本人工臓器学会大会 (54)
    • Place of Presentation
      米子市
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 皮下に埋植して作製した生体人工弁は次世代の代替心臓弁になり得るか?2016

    • Author(s)
      武輪能明、中山泰秀、住倉博仁、飯塚 慶、秋山大地、片桐伸将、竹下大輔、妙中義之、巽 英介
    • Organizer
      日本人工臓器学会大会 (54)
    • Place of Presentation
      米子市
    • Year and Date
      2016-11-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Long-term evaluation of a novel a autologous bioprothetic valve as a vital graft2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Iizuka K, Akiyama D, Kozaki S, Tatsumi E
    • Organizer
      American Heart Association Scientific Sessions 2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Long term evaluation of a novel versatile bioprosthetic valve made by autologous tissues2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Iizuka K, Katagiri N, Takeshita D, Tatsumi E
    • Organizer
      Annual Congress of the European Society for Artificial Organs (43)
    • Place of Presentation
      Warsaw
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel autologous heart valve with in-body tissue engineering2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Iizuka K, Akiyama D, Tatsumi E
    • Organizer
      2016 Annual Conference of the Asia-Pacific Society for Artificial Organs
    • Place of Presentation
      Tianjin
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel autologous heart valve with growth potential2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Iizuka K, Kanda E, Tatsumi E
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Rome
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A feasibility study of a novel autologous heart valve2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Iizuka K, Tatsumi E
    • Organizer
      American Society for Artificial Internal Organs (62)
    • Place of Presentation
      San Francisco
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a novel autologous bioprosthesis2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Tatsumi E
    • Organizer
      International Congress of the European Society for Cardiovascular and Endovascular Surgery (65)
    • Place of Presentation
      Belgrade
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel autologous heart valve with growth potential2016

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Tatsumi E
    • Organizer
      The Heart Valve Society Scientific Meeting 2016
    • Place of Presentation
      New York
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biovalve type SC: In vivo tissue-engineered autologous 3D heart valvular tissue. Mold design, excellent mechanical properties, valvular functions and in vivo performances2016

    • Author(s)
      Nakayama Y, Takewa Y, Sumikura H, Moriwaki T, Furukoshi M, Funayama M, Tatsumi E
    • Organizer
      The Heart Valve Society Scientific Meeting 2016
    • Place of Presentation
      New York
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 将来有望な自己組織からなる生体弁の開発研究2015

    • Author(s)
      武輪能明, 中山泰秀, 内藤敬嗣, 住倉博仁, 竹下大輔, 飯塚慶, 田中孝晴, 妙中義之, 巽英介
    • Organizer
      日本人工臓器学会大会 (53)
    • Place of Presentation
      文京区
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] A novel versatile bioprosthetic valve made by autologous tissues maintaining growth potential2015

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Iizuka K, Furukoshi M, Tanaka T, Tatsumi E
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orlando
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of in vivo, tissue-engineered, autologous, 3D heart valvular tissue, type SC biovalve with excellent mechanical properties, valvular functions, and in vivo performances2015

    • Author(s)
      Nakayama Y, Takewa Y, Moriwaki T, Sumikura H, Miyamoto S, Funayama M, Furukoshi M, Tatsumi E
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orlando
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improvement and evaluation of biovalve with stent for transcatheter pulmonary valve implantation2015

    • Author(s)
      Sumikura H, Nakayama Y, Ohnuma K, Takewa Y, Tatsumi E
    • Organizer
      Annual European Society for Artificial Organs Congress (42)
    • Place of Presentation
      Leuven
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a tailor made valve with autologous tissue2015

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Kanada K, Tajikawa T, Tanaka T, Tatsumi E
    • Organizer
      Annual European Society for Artificial Organs Congress (42)
    • Place of Presentation
      Leuven
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A tailor made valve surgery with a novel autologous bioprosthesis2015

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Naito N, Kanada K, Tajikawa T, Tanaka T, Tatsumi E
    • Organizer
      European Society of Cardiology Congress 2015
    • Place of Presentation
      London
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-body tissue engineered heart valve (biovalve) can be engrafted as vital tissues2015

    • Author(s)
      Takewa Y, Nakayama Y, Naito N, Sumikura H, Kanda K, Tajikawa T, Tatsumi E, Tanaka T
    • Organizer
      American Society for Artificial Internal Organs (61)
    • Place of Presentation
      Chicago
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of successful implantation of a novel autologous valve substitute(biovalve) with transcatheter technique2014

    • Author(s)
      Takewa Y, Nakayama Y, Kishimoto S, Date K, Sumikura H, Kanda K, Tajikawa T, Tanaka T, Taenaka Y, Tatsumi E
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体内組織形成術による次世代型自家組織心臓弁の開発2014

    • Author(s)
      武輪能明, 中山泰秀, 岸本 諭, 伊達数馬, 住倉 博仁, 神田圭一, 田地川 勉, 田中孝晴, 妙中義之, 巽 英介
    • Organizer
      日本人工臓器学会大会 (52)
    • Place of Presentation
      札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] チューブ型ステントバイオバルブにおける弁葉寸法の最適化2014

    • Author(s)
      住倉 博仁, 中山泰秀, 大沼健太郎, 武輪能明, 巽 英介
    • Organizer
      日本人工臓器学会大会 (52)
    • Place of Presentation
      札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 自己組織由来人工心臓弁(バイオバルブ)を用いた外科的大動脈弁置換術の動物実験評価2014

    • Author(s)
      岸本 諭, 武輪能明, 中山泰秀, 住倉 博仁, 伊達数馬, 西村元延, 巽 英介
    • Organizer
      日本人工臓器学会大会 (52)
    • Place of Presentation
      札幌市
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 自己組織からなる心臓弁 (Biovalve) の開発2014

    • Author(s)
      武輪能明, 中山泰秀, 岸本 諭, 伊達数馬, 住倉 博仁, 神田圭一, 田地川 勉, 田中孝晴, 妙中義之, 巽 英介
    • Organizer
      日本胸部外科学会定期学術集会 (67)
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-30 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] In vitro evaluation of a novel autologous biovalve with a stent for pulmonary valve2014

    • Author(s)
      Sumikura H, Nakayama Y, Ohnuma K, Takewa Y, Tatsumi E
    • Organizer
      Annual ESAO (European Society for Artificial Organs) Congress (41)
    • Place of Presentation
      Rome
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of a novel autologous heart valve (biovalve stent) for transcatheter implantation2014

    • Author(s)
      Takewa Y, Nakayama Y, Kishimoto S, Date K, Sumikura H, Kanda K, Tanaka T, Tatsumi E
    • Organizer
      Annual ESAO (European Society for Artificial Organs) Congress (41)
    • Place of Presentation
      Rome
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Pilot study of biovalve with stent as surgical aortic valve replacement in a goat model2014

    • Author(s)
      Kishimoto S, Takewa Y, Nakayama Y, Date K, Sumikura H, Nishimura M, Tatsumi E
    • Organizer
      Annual ESAO (European Society for Artificial Organs) Congress (41)
    • Place of Presentation
      Rome
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Histological change of a novel autologous tissue engineered heart valve after implantation2014

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Kishimoto S, Date K, Tajikawa T, Tanaka T, Tatsumi E
    • Organizer
      Biennial Meeting on Heart Valve Biology & Tissue Engineering (6)
    • Place of Presentation
      London
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Key factors to develop histogenesis in a novel autologous heart valve implantation2014

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Kishimoto S, Date K, Wieloch R, Kanada K, Tajikawa T, Tanaka T, Tatsumi E
    • Organizer
      European Society of Cardiology Congress 2014
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of noble autologous heart valve (Biovalve)2014

    • Author(s)
      Takewa Y, Nakayama Y, Sumikura H, Date K, Wieloch R, Kanda K, Tajikawa T, Tanaka T, Taenaka Y, Tatsumi E
    • Organizer
      American Society for Artificial Internal Organs (60)
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺動脈弁用ステントバイオバルブの IN VITRO 機能評価2014

    • Author(s)
      住倉 博仁, 中山泰秀, 大沼健太郎, 武輪能明, 巽 英介
    • Organizer
      日本バイオレオロジー学会年会 (37)
    • Place of Presentation
      さいたま市
    • Year and Date
      2014-06-05 – 2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Long term evaluation of in-body tissue engineered heart valve (Biovalve)2014

    • Author(s)
      Takewa Y, Nakayama Y, Kishimoto S, Date K, Sumikura H, Kanda K, Tajikawa T, Taenaka Y
    • Organizer
      Annual Joint Scientific Meeting of the Heart Valve Society of America and Society for Heart Valve Disease (6)
    • Place of Presentation
      New York
    • Year and Date
      2014-05-08 – 2014-05-10
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel autologous valve substitute (Biovalve) available for various type of cardiac valve protheses2014

    • Author(s)
      Takewa Y, Nakayama Y, Kishimoto S, Date K, Wieloch R, Sumikura H, Kanda K, Tajikawa T, Tanaka T, Taenaka Y, Tatsumi E
    • Organizer
      International Congress of the European Society for Cardiovascular and EndoVascular Surgery (63)
    • Place of Presentation
      Nice
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Preparation of an autologous heart valve with a stent(stent-biovalve) using the stent eversion method2014

    • Author(s)
      Nakayama Y, Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Moriwaki T, Yamanami M, Oie T, Tatsumi E, Kanda K
    • Organizer
      International Congress of the European Society for Cardiovascular and EndoVascular Surgery (63)
    • Place of Presentation
      Nice
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 自己組織心臓代用弁(バイオバルブ)の生体外機能評価2013

    • Author(s)
      住倉博仁、中山泰秀、大沼健太郎、武輪能明、巽英介
    • Organizer
      第36回日本バイオレオロジー学会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a novel autologous valve with a stent (Biovalve stent) for transcatheter implantation2013

    • Author(s)
      Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Kishimoto S, Atsuta Y, Ohnuma K, Sumikura H, Mizuno T, Kanda K, Tajikawa T, Taenaka Y, Tatsumi E
    • Organizer
      American Society for Artificial Internal Organs (59)
    • Place of Presentation
      Chicago
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a novel autologous valve with stent (Biovalave stent) for TAVI2013

    • Author(s)
      Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Ohnuma K, Sumikura H, Tajikawa T, Kanada K, Taenaka Y, Tatsumi E
    • Organizer
      Heart Valve Society of America 7th Biennial congress
    • Place of Presentation
      Venice
    • Related Report
      2013 Research-status Report
  • [Presentation] Systemic application of a completely autologous valved conduit (BIOVALVE Type VIII) prepared by in body tissue architecture technology in a goat model2013

    • Author(s)
      Nakayama Y, Takewa Y, Sumikura H, Yamanami M, Ohnuma K, Kanda K, Tatsumi E
    • Organizer
      Heart Valve Society of America 7th Biennial congress
    • Place of Presentation
      Venice
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of novel autologous heart valve (Biovalve Stent) for transcatheter aortic valve implantation2013

    • Author(s)
      Takewa Y, Kanada K, Nakayama Y, Sumikura H, Taenaka Y, Tajikawa T, Tatsumi E, Yamanami M
    • Organizer
      European Society for Artificial Organs (40)
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel stent eversion method for the preparation of autologous valve with stent (Stent-Biovalve)2013

    • Author(s)
      Mizuno T, Takewa Y, Sumikura H, Ohnuma K, Tsujinaka T, Yamanami M, Tatsumi E, Nakayama Y
    • Organizer
      European Society for Artificial Organs (40)
    • Place of Presentation
      Glasgow
    • Related Report
      2013 Research-status Report
  • [Presentation] 自己組織からなる心臓人工弁Biovalveの開発2013

    • Author(s)
      武輪能明、中山泰秀、山南将志、熱田祐一、岸本諭、伊達数馬、住倉博仁、大沼健太郎、水野荘司、神田圭一、田地川勉、田中孝晴、妙中義之、巽英介
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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