Application of in-body tissue-engineered heart valve (biovalve) to total artificial heart
Project/Area Number |
25670603
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular surgery
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Sumikura Hirohito 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (20433998)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | バイオバルブ / 全人工心臓 / 人工弁 / 自己組織 / 模擬循環回路 |
Outline of Final Research Achievements |
In this study, a biovalve for total artificial heart was developed using the "in-body tissue architecture" technology. A specially designed acrylic mold was placed in dorsal subcutaneous pouches of goats for 1-2 months. After extraction, the cylindrical mold was removed to obtain the biovalve. We fabricated three different forms of biovalves and evaluated their function in vitro using a mock circulation circuit to determine the optimal biovalve form for total artificial heart. The developed biovalves demonstrated good function in in vitro study. Based on the evaluation results of three kinds of biovalves, the biovalve for total artificial heart was developed.
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Report
(5 results)
Research Products
(51 results)
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[Journal Article] In-body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014
Author(s)
Nakayama Y, Takewa Y, Sumukura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohnuma K, Kanda K, Tatsumi E
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: (in press)
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fundamental Examination of an Application of Wearable Pneumatic Drive Unit for Pneumatic Total Artificial Heart System2014
Author(s)
住倉博仁, 本間章彦, 大沼健太郎, 妙中義之, 武輪能明, 梅木昭秀, 水野敏秀, 築谷朋典, 片桐伸将, 藤井 豊、角田幸秀、向林 宏、片野一夫、福井康裕、巽 英介
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Journal Title
IEEJ Transactions on Electronics, Information and Systems
Volume: 134
Issue: 6
Pages: 839-847
DOI
NAID
ISSN
0385-4221, 1348-8155
Related Report
Peer Reviewed
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[Presentation] Development of in vivo, tissue-engineered, autologous, 3D heart valvular tissue, type SC biovalve with excellent mechanical properties, valvular functions, and in vivo performances2015
Author(s)
Nakayama Y, Takewa Y, Moriwaki T, Sumikura H, Miyamoto S, Funayama M, Furukoshi M, Tatsumi E
Organizer
American Heart Association Scientific Sessions 2015
Place of Presentation
Orlando
Year and Date
2015-11-07
Related Report
Int'l Joint Research
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[Presentation] A novel autologous valve substitute (Biovalve) available for various type of cardiac valve protheses2014
Author(s)
Takewa Y, Nakayama Y, Kishimoto S, Date K, Wieloch R, Sumikura H, Kanda K, Tajikawa T, Tanaka T, Taenaka Y, Tatsumi E
Organizer
International Congress of the European Society for Cardiovascular and EndoVascular Surgery (63)
Place of Presentation
Nice
Year and Date
2014-04-24 – 2014-04-27
Related Report
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[Presentation] Development of a novel autologous valve with a stent (Biovalve stent) for transcatheter implantation2013
Author(s)
Takewa Y, Nakayama Y, Arakawa M, Yamanami M, Kishimoto S, Atsuta Y, Ohnuma K, Sumikura H, Mizuno T, Kanda K, Tajikawa T, Taenaka Y, Tatsumi E
Organizer
American Society for Artificial Internal Organs (59)
Place of Presentation
Chicago
Related Report
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